Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1111/gcb.13391 |
Inflammation, metaflammation and immunometabolic disorders | |
Hotamisligil, Gokhan S.1,2 | |
2017-02-09 | |
发表期刊 | NATURE
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ISSN | 0028-0836 |
EISSN | 1476-4687 |
出版年 | 2017 |
卷号 | 542期号:7640页码:177-185 |
文章类型 | Review |
语种 | 英语 |
国家 | USA |
英文摘要 | Proper regulation and management of energy, substrate diversity and quantity, as well as macromolecular synthesis and breakdown processes, are fundamental to cellular and organismal survival and are paramount to health. Cellular and multicellular organization are defended by the immune response, a robust and critical system through which self is distinguished from non-self, pathogenic signals are recognized and eliminated, and tissue homeostasis is safeguarded. Many layers of evolutionarily conserved interactions occur between immune response and metabolism. Proper maintenance of this delicate balance is crucial for health and has important implications for many pathological states such as obesity, diabetes, and other chronic non-communicable diseases. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000393737500030 |
WOS关键词 | INDUCED INSULIN-RESISTANCE ; ENDOPLASMIC-RETICULUM STRESS ; ADIPOSE-TISSUE INFLAMMATION ; NECROSIS-FACTOR-ALPHA ; DIET-INDUCED OBESITY ; REGULATORY T-CELLS ; SKELETAL-MUSCLE ; METABOLIC DYSFUNCTION ; FATTY-ACIDS ; ER STRESS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/16997 |
专题 | 气候变化 资源环境科学 |
作者单位 | 1.Broad Inst Harvard & MIT, Harvard TH Chan Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA 02115 USA; 2.Broad Inst Harvard & MIT, Harvard TH Chan Sch Publ Hlth, Sabri Ulker Ctr, Boston, MA 02115 USA |
推荐引用方式 GB/T 7714 | Hotamisligil, Gokhan S.. Inflammation, metaflammation and immunometabolic disorders[J]. NATURE,2017,542(7640):177-185. |
APA | Hotamisligil, Gokhan S..(2017).Inflammation, metaflammation and immunometabolic disorders.NATURE,542(7640),177-185. |
MLA | Hotamisligil, Gokhan S.."Inflammation, metaflammation and immunometabolic disorders".NATURE 542.7640(2017):177-185. |
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