GSTDTAP  > 气候变化
DOI10.1111/gcb.13391
Inflammation, metaflammation and immunometabolic disorders
Hotamisligil, Gokhan S.1,2
2017-02-09
发表期刊NATURE
ISSN0028-0836
EISSN1476-4687
出版年2017
卷号542期号:7640页码:177-185
文章类型Review
语种英语
国家USA
英文摘要

Proper regulation and management of energy, substrate diversity and quantity, as well as macromolecular synthesis and breakdown processes, are fundamental to cellular and organismal survival and are paramount to health. Cellular and multicellular organization are defended by the immune response, a robust and critical system through which self is distinguished from non-self, pathogenic signals are recognized and eliminated, and tissue homeostasis is safeguarded. Many layers of evolutionarily conserved interactions occur between immune response and metabolism. Proper maintenance of this delicate balance is crucial for health and has important implications for many pathological states such as obesity, diabetes, and other chronic non-communicable diseases.


领域地球科学 ; 气候变化 ; 资源环境
收录类别SCI-E
WOS记录号WOS:000393737500030
WOS关键词INDUCED INSULIN-RESISTANCE ; ENDOPLASMIC-RETICULUM STRESS ; ADIPOSE-TISSUE INFLAMMATION ; NECROSIS-FACTOR-ALPHA ; DIET-INDUCED OBESITY ; REGULATORY T-CELLS ; SKELETAL-MUSCLE ; METABOLIC DYSFUNCTION ; FATTY-ACIDS ; ER STRESS
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
引用统计
文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/16997
专题气候变化
资源环境科学
作者单位1.Broad Inst Harvard & MIT, Harvard TH Chan Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA 02115 USA;
2.Broad Inst Harvard & MIT, Harvard TH Chan Sch Publ Hlth, Sabri Ulker Ctr, Boston, MA 02115 USA
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GB/T 7714
Hotamisligil, Gokhan S.. Inflammation, metaflammation and immunometabolic disorders[J]. NATURE,2017,542(7640):177-185.
APA Hotamisligil, Gokhan S..(2017).Inflammation, metaflammation and immunometabolic disorders.NATURE,542(7640),177-185.
MLA Hotamisligil, Gokhan S.."Inflammation, metaflammation and immunometabolic disorders".NATURE 542.7640(2017):177-185.
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