Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP3954 |
Environmental Styrene Exposure and Sensory and Motor Function in Gulf Coast Residents | |
Werder, Emily J.1,2; Sandler, Dale P.1; Richardson, David B.2; Emch, Michael E.2; Kwok, Richard K.1; Gerr, Fredric E.3; Engel, Lawrence S.1,2 | |
2019-04-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES
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ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2019 |
卷号 | 127期号:4 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | BACKGROUND: Although styrene is an established neurotoxicant at occupational exposure levels, its neurotoxicity has not been characterized in relation to general population exposures. Further, occupational research to date has focused on central nervous system impairment. OBJECTIVE: We assessed styrene-associated differences in sensory and motor function among Gulf coast residents. METHODS: We used 2011 National Air Toxics Assessment estimates of ambient styrene to determine exposure levels for 2,956 nondiabetic Gulf state residents enrolled in the Gulf Long-term Follow-up Study, and additionally measured blood styrene concentration in a subset of participants 1 to 2 y after enrollment (n = 310). Participants completed an enrollment telephone interview and a comprehensive test battery to assess sensory and motor function during a clinical follow-up exam 2 to 4 y later. Detailed covariate information was ascertained at enrollment via telephone interview. We used multivariate linear regression to estimate continuous differences in sensory and motor function, and log-binomial regression to estimate prevalence ratios for dichotomous outcomes. We estimated associations of both ambient and blood styrene exposures with sensory and motor function, independently for five unique tests. RESULTS: Those participants in the highest 25% vs. lowest 75% of ambient exposure and those in the highest 10% vs. lowest 90% of blood styrene had slightly diminished visual contrast sensitivity. Mean vibmtactile thresholds were lower among those in the highest vs. lowest quartile of ambient styrene and the highest 10% vs. lowest 90% of blood styrene (-0.13 log microns; 95% CI: -0.23, -0.03 and -0.39 log microns; 95% CI: -0.72, -0.05, respectively). The highest vs. lowest quartile of ambient styrene was associated with significantly poorer postural stability, and (unexpectedly) with significantly greater grip strength. DISCUSSION: We observed associations between higher styrene exposure and poorer visual, sensory, and vestibular function, though we did not detect associations with reduced voluntary motor system performance. Associations were more consistent for ambient exposures, but we also found notable associations with measured blood styrene. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000467131100005 |
WOS关键词 | SOLID-PHASE MICROEXTRACTION ; VOLATILE ORGANIC-COMPOUNDS ; PERIPHERAL-NERVE FUNCTION ; COLOR-VISION LOSS ; OCCUPATIONAL-EXPOSURE ; POSTURAL STABILITY ; SYSTEM FUNCTION ; N-HEXANE ; WORKERS ; BLOOD |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/182025 |
专题 | 资源环境科学 |
作者单位 | 1.NIEHS, Epidemiol Branch, NIH, Res Triangle Pk, NC 27709 USA; 2.Univ N Carolina, Epidemiol Dept, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27515 USA; 3.Univ Iowa, Dept Occupat & Environm Hlth, Coll Publ Hlth, Iowa City, IA USA |
推荐引用方式 GB/T 7714 | Werder, Emily J.,Sandler, Dale P.,Richardson, David B.,et al. Environmental Styrene Exposure and Sensory and Motor Function in Gulf Coast Residents[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2019,127(4). |
APA | Werder, Emily J..,Sandler, Dale P..,Richardson, David B..,Emch, Michael E..,Kwok, Richard K..,...&Engel, Lawrence S..(2019).Environmental Styrene Exposure and Sensory and Motor Function in Gulf Coast Residents.ENVIRONMENTAL HEALTH PERSPECTIVES,127(4). |
MLA | Werder, Emily J.,et al."Environmental Styrene Exposure and Sensory and Motor Function in Gulf Coast Residents".ENVIRONMENTAL HEALTH PERSPECTIVES 127.4(2019). |
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