Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP3286 |
The Association between Long-Term Air Pollution and Urinary Catecholamines: Evidence from the Multi-Ethnic Study of Atherosclerosis | |
Hajat, Anjum1; Roux, Ana V. Diez2; Castro-Diehl, Cecilia3,4; Cosselman, Kristen5; HillGolden, Sherita6; Hazlehurst, Marnie F.5; Szpiro, Adam7; Vedal, Sverre5; Kaufman, Joel D.1,5 | |
2019-05-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2019 |
卷号 | 127期号:5 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | BACKGROUND: Autonomic nervous system effects have been hypothesized as a mechanism of air pollutant health effects, though scant prior epidemiologic research has examined the association between air pollutants and catecholamines. OBJECTIVES: To examine the association of long-term air pollutants with three urinary catecholamines: dopamine (DA), epinephrine (EPI), and nor epinephrine (NE). As a secondary aim, we also examined the association between short-term (or acute) exposure to fine particulate matter [particulate matter with aerodynamic diameter <= 2.5 mu m (PM2.5)] and those catecholamines. METHODS: We used data from the Multi-Ethnic Study of Atherosclerosis (MESA) and two of its ancillary studies, the MESA Air Pollution Study and the MESA Stress Study, to provide exposure and outcome data. DA, EFL and NE from urine samples were collected from 2004 to 2006 from 1,002 participants in the New York, New York, and Los Angeles, California, study sites. Spatimemporal models incorporated cohort-specific monitoring and estimated annual average pollutant concentrations (PM2.5, NO2, NOx, and black carbon) at participants' homes thc year prior to urine collection. Secondarily, short-term PM2.5 was evaluated (day of, day prior, and 2-to 5-cl lags prior to urine collection). Several covariates were considered confounders (age, race, scx, site, socioeconomic status, cardiovascular disease risk factors, psychosocial stressors, and medication use) in linear regression models. RESULTS: A 17 ppb higher annual NOx concentration was associated with 6.3% higher mean EPI level [95% confidence interval (CI): 0.3%, 12.6%]. A 2-mu g/m(3) higher annual ambient PM2.5 concentration was associated with 9.1% higher mean EPI (95% CI: 3.2%, 15.3%) and 4.4% higher DA level (95% Cl: 1%, 7.9%). NO2, black carbon, and short-term PM2.5 exposures were not significantly associated with any of the catecholamines. CONCLUSIONS: We found an association between EPI and long-term concentrations of PM2.5 and NO, and an association between DA and long-term ambient PM2.5. These novel findings provide modest support for the hypothesis that air pollutant exposures are related to sympathetic nervous system activation. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000471116100003 |
WOS关键词 | PARTICULATE MATTER ; CARDIOVASCULAR-DISEASE ; STRESS HORMONES ; EXPOSURE ; PM2.5 ; ACTIVATION ; EXCRETION ; BLOOD |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/182818 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA; 2.Drexel Univ, Dept Epidemiol & Biostat, Philadelphia, PA 19104 USA; 3.Boston Univ, Sch Med, Dept Med, Sect Prevent Med, Boston, MA 02118 USA; 4.Boston Univ, Sch Med, Dept Med, Sect Epidemiol & Cardiol, Boston, MA 02118 USA; 5.Univ Washington, Dept Environm & Occupat Hlth Sci, Seattle, WA 98195 USA; 6.Johns Hopkins Univ, Dept Med, Div Endocrinol Diabet & Metab, Baltimore, MD USA; 7.Univ Washington, Dept Biostat, Seattle, WA 98195 USA |
推荐引用方式 GB/T 7714 | Hajat, Anjum,Roux, Ana V. Diez,Castro-Diehl, Cecilia,et al. The Association between Long-Term Air Pollution and Urinary Catecholamines: Evidence from the Multi-Ethnic Study of Atherosclerosis[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2019,127(5). |
APA | Hajat, Anjum.,Roux, Ana V. Diez.,Castro-Diehl, Cecilia.,Cosselman, Kristen.,HillGolden, Sherita.,...&Kaufman, Joel D..(2019).The Association between Long-Term Air Pollution and Urinary Catecholamines: Evidence from the Multi-Ethnic Study of Atherosclerosis.ENVIRONMENTAL HEALTH PERSPECTIVES,127(5). |
MLA | Hajat, Anjum,et al."The Association between Long-Term Air Pollution and Urinary Catecholamines: Evidence from the Multi-Ethnic Study of Atherosclerosis".ENVIRONMENTAL HEALTH PERSPECTIVES 127.5(2019). |
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