GSTDTAP  > 资源环境科学
DOI10.1289/EHP4093
Tap Water Contributions to Plasma Concentrations of Poly- and Perfluoroalkyl Substances (PFAS) in a Nationwide Prospective Cohort of US Women
Hu, Xindi C.1,2; Tokranov, Andrea K.2; Liddie, Jahred2; Zhang, Xianming2; Grandjean, Philippe1,3; Hart, Jaime E.1,4,5; Laden, Francine1,4,5,6; Sun, Qi4,5,7; Yeung, Leo W. Y.8; Sunderland, Elsie M.1,2
2019-06-01
发表期刊ENVIRONMENTAL HEALTH PERSPECTIVES
ISSN0091-6765
EISSN1552-9924
出版年2019
卷号127期号:6
文章类型Article
语种英语
国家USA; Denmark; Sweden
英文摘要

BACKGROUND: Between 2013 and 2015, concentrations of poly- and perfluoroalkyl substances (PFAS) in public drinking water supplies serving at least six million individuals exceeded the level set forth in the health advisory established by the U.S. Environmental Protection Agency. Other than data reported for contaminated sites, no systematic or prospective data exist on the relative source contribution (RSC) of drinking water to human PFAS exposures.


OBJECTIVES: This study estimates the RSC of tap water to overall PFAS exposure among members of the general U.S. population.


METHODS: We measured concentrations of 15 PFAS in home tap water samples collected in 1989-1990 from 225 participants in a nationwide prospective cohort of U.S. women: the Nurses' Health Study (NHS). We used a one-compartment toxicokinetic model to estimate plasma concentrations corresponding to tap water intake of PFAS. We compared modeled results with measured plasma PFAS concentrations among a subset of 110 NHS participants.


RESULTS: Tap water perfluorooctanoic acid (PFOA) and perfluorononanoic acid (PFNA) were statistically significant predictors of plasma concentrations among individuals who consumed >= 8 cups of tap water per day. Modeled median contributions of tap water to measured plasma concentrations were: PFOA 12% (95% probability interval 11%-14%), PFNA 13% (8.7%-21%), linear perfluorooctanesulfonic acid (nPFOS) 2.2% (2.0%-2.5%), branched perfluorooctanesulfonic acid (brPFOS) 3.0% (2.5%-3.2%), and perfluorohexanesulfonic acid (PFHxS) 34% (29%-39%). In live locations, comparisons of PFASs in community tap water collected in the period 2013-2016 with samples from 1989-1990 indicated increases in quantifiable PFAS and extractable organic fluorine (a proxy for unquantified PFAS).


CONCLUSIONS: Our results for 1989-1990 compare well with the default RSC of 20% used in risk assessments for legacy PFAS by many agencies. Future evaluation of drinking water exposures should incorporate emerging PFAS.


领域资源环境
收录类别SCI-E
WOS记录号WOS:000474528700004
WOS关键词PERFLUOROOCTANOIC ACID PFOA ; DRINKING-WATER ; POLYFLUOROALKYL SUBSTANCES ; HUMAN EXPOSURE ; SERUM CONCENTRATIONS ; SULFONIC-ACIDS ; PERFLUORINATED COMPOUNDS ; SENSITIVE METHOD ; PFCA HOMOLOGS ; POPULATION
WOS类目Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology
WOS研究方向Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology
引用统计
文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/183727
专题资源环境科学
作者单位1.Harvard Univ, Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA;
2.Harvard Univ, Harvard John A Paulson Sch Engn & Appl Sci, Cambridge, MA 02138 USA;
3.Univ Southern Denmark, Inst Publ Hlth, Odense, Denmark;
4.Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA;
5.Harvard Med Sch, Boston, MA 02115 USA;
6.Harvard Univ, Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA;
7.Harvard Univ, Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA;
8.Orebro Univ, Sch Sci & Technol, MTM Res Ctr, Orebro, Sweden
推荐引用方式
GB/T 7714
Hu, Xindi C.,Tokranov, Andrea K.,Liddie, Jahred,et al. Tap Water Contributions to Plasma Concentrations of Poly- and Perfluoroalkyl Substances (PFAS) in a Nationwide Prospective Cohort of US Women[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2019,127(6).
APA Hu, Xindi C..,Tokranov, Andrea K..,Liddie, Jahred.,Zhang, Xianming.,Grandjean, Philippe.,...&Sunderland, Elsie M..(2019).Tap Water Contributions to Plasma Concentrations of Poly- and Perfluoroalkyl Substances (PFAS) in a Nationwide Prospective Cohort of US Women.ENVIRONMENTAL HEALTH PERSPECTIVES,127(6).
MLA Hu, Xindi C.,et al."Tap Water Contributions to Plasma Concentrations of Poly- and Perfluoroalkyl Substances (PFAS) in a Nationwide Prospective Cohort of US Women".ENVIRONMENTAL HEALTH PERSPECTIVES 127.6(2019).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Hu, Xindi C.]的文章
[Tokranov, Andrea K.]的文章
[Liddie, Jahred]的文章
百度学术
百度学术中相似的文章
[Hu, Xindi C.]的文章
[Tokranov, Andrea K.]的文章
[Liddie, Jahred]的文章
必应学术
必应学术中相似的文章
[Hu, Xindi C.]的文章
[Tokranov, Andrea K.]的文章
[Liddie, Jahred]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。