Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP4093 |
Tap Water Contributions to Plasma Concentrations of Poly- and Perfluoroalkyl Substances (PFAS) in a Nationwide Prospective Cohort of US Women | |
Hu, Xindi C.1,2; Tokranov, Andrea K.2; Liddie, Jahred2; Zhang, Xianming2; Grandjean, Philippe1,3; Hart, Jaime E.1,4,5; Laden, Francine1,4,5,6; Sun, Qi4,5,7; Yeung, Leo W. Y.8; Sunderland, Elsie M.1,2 | |
2019-06-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES
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ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2019 |
卷号 | 127期号:6 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Denmark; Sweden |
英文摘要 | BACKGROUND: Between 2013 and 2015, concentrations of poly- and perfluoroalkyl substances (PFAS) in public drinking water supplies serving at least six million individuals exceeded the level set forth in the health advisory established by the U.S. Environmental Protection Agency. Other than data reported for contaminated sites, no systematic or prospective data exist on the relative source contribution (RSC) of drinking water to human PFAS exposures. OBJECTIVES: This study estimates the RSC of tap water to overall PFAS exposure among members of the general U.S. population. METHODS: We measured concentrations of 15 PFAS in home tap water samples collected in 1989-1990 from 225 participants in a nationwide prospective cohort of U.S. women: the Nurses' Health Study (NHS). We used a one-compartment toxicokinetic model to estimate plasma concentrations corresponding to tap water intake of PFAS. We compared modeled results with measured plasma PFAS concentrations among a subset of 110 NHS participants. RESULTS: Tap water perfluorooctanoic acid (PFOA) and perfluorononanoic acid (PFNA) were statistically significant predictors of plasma concentrations among individuals who consumed >= 8 cups of tap water per day. Modeled median contributions of tap water to measured plasma concentrations were: PFOA 12% (95% probability interval 11%-14%), PFNA 13% (8.7%-21%), linear perfluorooctanesulfonic acid (nPFOS) 2.2% (2.0%-2.5%), branched perfluorooctanesulfonic acid (brPFOS) 3.0% (2.5%-3.2%), and perfluorohexanesulfonic acid (PFHxS) 34% (29%-39%). In live locations, comparisons of PFASs in community tap water collected in the period 2013-2016 with samples from 1989-1990 indicated increases in quantifiable PFAS and extractable organic fluorine (a proxy for unquantified PFAS). CONCLUSIONS: Our results for 1989-1990 compare well with the default RSC of 20% used in risk assessments for legacy PFAS by many agencies. Future evaluation of drinking water exposures should incorporate emerging PFAS. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000474528700004 |
WOS关键词 | PERFLUOROOCTANOIC ACID PFOA ; DRINKING-WATER ; POLYFLUOROALKYL SUBSTANCES ; HUMAN EXPOSURE ; SERUM CONCENTRATIONS ; SULFONIC-ACIDS ; PERFLUORINATED COMPOUNDS ; SENSITIVE METHOD ; PFCA HOMOLOGS ; POPULATION |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/183727 |
专题 | 资源环境科学 |
作者单位 | 1.Harvard Univ, Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA; 2.Harvard Univ, Harvard John A Paulson Sch Engn & Appl Sci, Cambridge, MA 02138 USA; 3.Univ Southern Denmark, Inst Publ Hlth, Odense, Denmark; 4.Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA; 5.Harvard Med Sch, Boston, MA 02115 USA; 6.Harvard Univ, Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA; 7.Harvard Univ, Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA; 8.Orebro Univ, Sch Sci & Technol, MTM Res Ctr, Orebro, Sweden |
推荐引用方式 GB/T 7714 | Hu, Xindi C.,Tokranov, Andrea K.,Liddie, Jahred,et al. Tap Water Contributions to Plasma Concentrations of Poly- and Perfluoroalkyl Substances (PFAS) in a Nationwide Prospective Cohort of US Women[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2019,127(6). |
APA | Hu, Xindi C..,Tokranov, Andrea K..,Liddie, Jahred.,Zhang, Xianming.,Grandjean, Philippe.,...&Sunderland, Elsie M..(2019).Tap Water Contributions to Plasma Concentrations of Poly- and Perfluoroalkyl Substances (PFAS) in a Nationwide Prospective Cohort of US Women.ENVIRONMENTAL HEALTH PERSPECTIVES,127(6). |
MLA | Hu, Xindi C.,et al."Tap Water Contributions to Plasma Concentrations of Poly- and Perfluoroalkyl Substances (PFAS) in a Nationwide Prospective Cohort of US Women".ENVIRONMENTAL HEALTH PERSPECTIVES 127.6(2019). |
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