Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP4849 |
Using Birth Cohort Data to Estimate Prenatal Chemical Exposures for All Births around the New Bedford Harbor Superfund Site in Massachusetts | |
Khalili, Roxana1; Bartell, Scott M.1,2,3,4; Levy, Jonathan L.5,6; Fabian, M. Patricia5,6; Korrick, Susan6,7,8; Vieira, Veronica M.1,2 | |
2019-08-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES
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ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2019 |
卷号 | 127期号:8 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | BACKGROUND: Children born near New Bedford, Massachusetts, have been prenatally exposed to multiple environmental chemicals, in part due to an older housing stock, maternal diet, and proximity to the New Bedford Harbor (NBH) Superfund site. Chemical exposure measures are not available for all births, limiting epidemiologic investigations and potential interventions. OBJECTIVE: We linked biomonitoring data from the New Bedford Cohort (NBC) and birth record data to predict prenatal exposures for all contemporaneous area births. METHODS: We used prenatal exposure biomarker data from the NBC, a population-based cohort of 788 mother-infant pairs born during 1993-1998 to mothers living near the NBH, linked to their corresponding Massachusetts birth record data, to build predictive models for cord serum polychlorinated biphenyls (expressed as a sum, Sigma PCBs), p,p'-dichlomdiphenyl dichloroethylene (DDE), hexachlorobenzene (HCB), cord blood lead (Pb), and maternal hair mercury (Hg). We applied the best fit models (highest pseudo R-2), with multivariable smooths of continuous variables, to predict exposure biomarkers for all 10,270 births during 1993-1998 around the NBH. We used 10-fold cross validation to validate the exposure models and the bootstrap method to characterize sampling variability in the exposure predictions. RESULTS: The 10-fold cross-validated R-2 for the Sigma PCBs, DDE, HCB, Pb, and Hg exposure models were 0.54,0.40,0.34,0.46, and 0.40, respectively. For each exposure model, multivariable smooths of continuous variables improved the fit compared with linear models. Other variables with significant effects on exposure estimates were paternal education, maternal race/ethnicity, and maternal ancestry. The resulting exposure predictions for all births had variability consistent with the NBC measured exposures. CONCLUSIONS: Predictive models using multivariable smoothing explained reasonable amounts of variance in prenatal exposure biomarkers. Our analyses suggest that prenatal chemical exposures can be predicted for all contemporaneous births in the same geographic area by modeling available biomarker data for a subset of that population. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000483734400006 |
WOS关键词 | POLYCHLORINATED-BIPHENYLS ; LEAD-EXPOSURE ; ORGANOCHLORINE EXPOSURE ; FISH CONSUMPTION ; INUIT INFANTS ; AIR-POLLUTION ; US WOMEN ; CHILDREN ; PCB ; INFECTIONS |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/185563 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Calif Irvine, Susan & Henry Samueli Coll Hlth Sci, Environm Hlth Sci Grad Program, Irvine, CA USA; 2.Univ Calif Irvine, Susan & Henry Samueli Coll Hlth Sci, Program Publ Hlth, Irvine, CA USA; 3.Univ Calif Irvine, Donald Bren Sch Informat & Comp Sci, Dept Stat, Irvine, CA USA; 4.Univ Calif Irvine, Susan & Henry Samueli Coll Hlth Sci, Sch Med, Dept Epidemiol, Irvine, CA USA; 5.Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA; 6.Harvard TH Chan Sch Publ Hlth, Dept Environm & Lealth, Boston, MA USA; 7.Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA; 8.Harvard Med Sch, Boston, MA 02115 USA |
推荐引用方式 GB/T 7714 | Khalili, Roxana,Bartell, Scott M.,Levy, Jonathan L.,et al. Using Birth Cohort Data to Estimate Prenatal Chemical Exposures for All Births around the New Bedford Harbor Superfund Site in Massachusetts[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2019,127(8). |
APA | Khalili, Roxana,Bartell, Scott M.,Levy, Jonathan L.,Fabian, M. Patricia,Korrick, Susan,&Vieira, Veronica M..(2019).Using Birth Cohort Data to Estimate Prenatal Chemical Exposures for All Births around the New Bedford Harbor Superfund Site in Massachusetts.ENVIRONMENTAL HEALTH PERSPECTIVES,127(8). |
MLA | Khalili, Roxana,et al."Using Birth Cohort Data to Estimate Prenatal Chemical Exposures for All Births around the New Bedford Harbor Superfund Site in Massachusetts".ENVIRONMENTAL HEALTH PERSPECTIVES 127.8(2019). |
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