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DOI | 10.1126/science.aal2415 |
The structure of the yeast mitochondrial ribosome | |
Desai, Nirupa1; Brown, Alan1; Amunts, Alexey1,2; Ramakrishnan, V.1 | |
2017-02-03 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 355期号:6324页码:528-531 |
文章类型 | Article |
语种 | 英语 |
国家 | England; Sweden |
英文摘要 | Mitochondria have specialized ribosomes (mitoribosomes) dedicated to the expression of the genetic information encoded by their genomes. Here, using electron cryomicroscopy, we have determined the structure of the 75-component yeast mitoribosome to an overall resolution of 3.3 angstroms. The mitoribosomal small subunit has been built de novo and includes 15S ribosomal RNA (rRNA) and 34 proteins, including 14 without homologs in the evolutionarily related bacterial ribosome. Yeast-specific rRNA and protein elements, including the acquisition of a putatively active enzyme, give the mitoribosome a distinct architecture compared to the mammalian mitoribosome. At an expanded messenger RNA channel exit, there is a binding platform for translational activators that regulate translation in yeast but not mammalian mitochondria. The structure provides insights into the evolution and species-specific specialization of mitochondrial translation. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000393183100046 |
WOS关键词 | MESSENGER-RNA ; TRANSLATIONAL ACTIVATOR ; SACCHAROMYCES-CEREVISIAE ; FUNCTIONAL INTERACTIONS ; PROTEIN-SYNTHESIS ; SUBUNIT ; IDENTIFICATION ; ORGANIZATION ; EVOLUTION ; HOMOLOGS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/195355 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.MRC Lab Mol Biol, Francis Crick Ave, Cambridge CB2 0QH, England; 2.Stockholm Univ, SciLifeLab, SE-10691 Stockholm, Sweden |
推荐引用方式 GB/T 7714 | Desai, Nirupa,Brown, Alan,Amunts, Alexey,et al. The structure of the yeast mitochondrial ribosome[J]. SCIENCE,2017,355(6324):528-531. |
APA | Desai, Nirupa,Brown, Alan,Amunts, Alexey,&Ramakrishnan, V..(2017).The structure of the yeast mitochondrial ribosome.SCIENCE,355(6324),528-531. |
MLA | Desai, Nirupa,et al."The structure of the yeast mitochondrial ribosome".SCIENCE 355.6324(2017):528-531. |
条目包含的文件 | 条目无相关文件。 |
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