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DOI | 10.1126/science.aai8355 |
Homer1a drives homeostatic scaling-down of excitatory synapses during sleep | |
Diering, Graham H.1; Nirujogi, Raja S.2; Roth, Richard H.1; Worley, Paul F.1; Pandey, Akhilesh2; Huganir, Richard L.1 | |
2017-02-03 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 355期号:6324页码:511-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Sleep is an essential process that supports learning and memory by acting on synapses through poorly understood molecular mechanisms. Using biochemistry, proteomics, and imaging in mice, we find that during sleep, synapses undergo widespread alterations in composition and signaling, including weakening of synapses through removal and dephosphorylation of synaptic AMPA-type glutamate receptors. These changes are driven by the immediate early gene Homer1a and signaling from group I metabotropic glutamate receptors mGluR1/5. Homer1a serves as a molecular integrator of arousal and sleep need via the wake- and sleep-promoting neuromodulators, noradrenaline and adenosine, respectively. Our data suggest that homeostatic scaling-down, a global form of synaptic plasticity, is active during sleep to remodel synapses and participates in the consolidation of contextual memory. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000393183100042 |
WOS关键词 | METABOTROPIC GLUTAMATE RECEPTORS ; SYNAPTIC PLASTICITY ; ACTIVATION ; MEMORY ; WAKE ; MODULATION ; MICE ; DEPRIVATION ; PERSISTENCE ; PROTEIN |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/195359 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Johns Hopkins Univ, Kavli Neurosci Discovery Inst, Solomon Snyder Dept Neurosci, Baltimore, MD 21218 USA; 2.Johns Hopkins Univ, Inst Med Genet, Dept Biol Chem, Baltimore, MD USA |
推荐引用方式 GB/T 7714 | Diering, Graham H.,Nirujogi, Raja S.,Roth, Richard H.,et al. Homer1a drives homeostatic scaling-down of excitatory synapses during sleep[J]. SCIENCE,2017,355(6324):511-+. |
APA | Diering, Graham H.,Nirujogi, Raja S.,Roth, Richard H.,Worley, Paul F.,Pandey, Akhilesh,&Huganir, Richard L..(2017).Homer1a drives homeostatic scaling-down of excitatory synapses during sleep.SCIENCE,355(6324),511-+. |
MLA | Diering, Graham H.,et al."Homer1a drives homeostatic scaling-down of excitatory synapses during sleep".SCIENCE 355.6324(2017):511-+. |
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