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DOI | 10.1126/science.aak9995 |
GTPase activity-coupled treadmilling of the bacterial tubulin FtsZ organizes septal cell wall synthesis | |
Yang, Xinxing1; Lyu, Zhixin1; Miguel, Amanda2; McQuillen, Ryan1; Huang, Kerwyn Casey2,3; Xiao, Jie1 | |
2017-02-17 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 355期号:6326页码:744-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | The bacterial tubulin FtsZ is the central component of the cell division machinery, coordinating an ensemble of proteins involved in septal cell wall synthesis to ensure successful constriction. How cells achieve this coordination is unknown. We found that in Escherichia coli cells, FtsZ exhibits dynamic treadmilling predominantly determined by its guanosine triphosphatase activity. The treadmilling dynamics direct the processive movement of the septal cell wall synthesis machinery but do not limit the rate of septal synthesis. In FtsZ mutants with severely reduced treadmilling, the spatial distribution of septal synthesis and the molecular composition and ultrastructure of the septal cell wall were substantially altered. Thus, FtsZ treadmilling provides a mechanism for achieving uniform septal cell wall synthesis to enable correct polar morphology. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000395117700042 |
WOS关键词 | DIVISION PROTEIN FTSZ ; Z-RING STRUCTURE ; SUPERRESOLUTION ; PEPTIDOGLYCAN ; MUTATIONS ; DYNAMICS ; MUTANTS ; BINDING |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/195454 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Johns Hopkins Univ, Dept Biophys & Biophys Chem, Sch Med, Baltimore, MD 21205 USA; 2.Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA; 3.Stanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USA |
推荐引用方式 GB/T 7714 | Yang, Xinxing,Lyu, Zhixin,Miguel, Amanda,et al. GTPase activity-coupled treadmilling of the bacterial tubulin FtsZ organizes septal cell wall synthesis[J]. SCIENCE,2017,355(6326):744-+. |
APA | Yang, Xinxing,Lyu, Zhixin,Miguel, Amanda,McQuillen, Ryan,Huang, Kerwyn Casey,&Xiao, Jie.(2017).GTPase activity-coupled treadmilling of the bacterial tubulin FtsZ organizes septal cell wall synthesis.SCIENCE,355(6326),744-+. |
MLA | Yang, Xinxing,et al."GTPase activity-coupled treadmilling of the bacterial tubulin FtsZ organizes septal cell wall synthesis".SCIENCE 355.6326(2017):744-+. |
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