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DOI | 10.1126/science.aah6171 |
Lipid transport by TMEM24 at ER-plasma membrane contacts regulates pulsatile insulin secretion | |
Lees, Joshua A.1; Messa, Mirko1,2,3,4; Sun, Elizabeth Wen1,2,3,4; Wheeler, Heather1,2,3,4; Torta, Federico6; Wenk, Markus R.6; De Camilli, Pietro1,2,3,4,5; Reinisch, Karin M.1 | |
2017-02-17 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 355期号:6326 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Singapore |
英文摘要 | Insulin is released by beta cells in pulses regulated by calcium and phosphoinositide signaling. Here, we describe how transmembrane protein 24 (TMEM24) helps coordinate these signaling events. We showed that TMEM24 is an endoplasmic reticulum (ER)-anchored membrane protein whose reversible localization to ER-plasma membrane (PM) contacts is governed by phosphorylation and dephosphorylation in response to oscillations in cytosolic calcium. A lipid-binding module in TMEM24 transports the phosphatidylinositol 4,5-bisphosphate [PI(4,5)P-2] precursor phosphatidylinositol between bilayers, allowing replenishment of PI(4,5)P-2 hydrolyzed during signaling. In the absence of TMEM24, calcium oscillations are abolished, leading to a defect in triggered insulin release. Our findings implicate direct lipid transport between the ER and the PM in the control of insulin secretion, a process impaired in patients with type II diabetes. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000395117700032 |
WOS关键词 | BINDING PROTEINS ; PHOSPHATIDYLSERINE TRANSPORT ; CALCIUM OSCILLATIONS ; TULIP SUPERFAMILY ; SMP DOMAINS ; EXCHANGE ; PHOSPHOLIPIDS ; SITES ; PHOSPHORYLATION ; IDENTIFICATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/195461 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Yale Univ, Dept Cell Biol, Sch Med, New Haven, CT 06520 USA; 2.Yale Univ, Dept Neurosci, Sch Med, New Haven, CT 06510 USA; 3.Yale Univ, Howard Hughes Med Inst, Sch Med, New Haven, CT 06510 USA; 4.Yale Univ, Program Cellular Neurosci Neurodegenerat & Repair, Sch Med, New Haven, CT 06510 USA; 5.Yale Univ, Kavli Inst Neurosci, Sch Med, New Haven, CT 06510 USA; 6.Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biochem, Singapore 117599, Singapore |
推荐引用方式 GB/T 7714 | Lees, Joshua A.,Messa, Mirko,Sun, Elizabeth Wen,et al. Lipid transport by TMEM24 at ER-plasma membrane contacts regulates pulsatile insulin secretion[J]. SCIENCE,2017,355(6326). |
APA | Lees, Joshua A..,Messa, Mirko.,Sun, Elizabeth Wen.,Wheeler, Heather.,Torta, Federico.,...&Reinisch, Karin M..(2017).Lipid transport by TMEM24 at ER-plasma membrane contacts regulates pulsatile insulin secretion.SCIENCE,355(6326). |
MLA | Lees, Joshua A.,et al."Lipid transport by TMEM24 at ER-plasma membrane contacts regulates pulsatile insulin secretion".SCIENCE 355.6326(2017). |
条目包含的文件 | 条目无相关文件。 |
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