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DOI | 10.1126/science.aaf4901 |
The cytotoxic Staphylococcus aureus PSM alpha a3 reveals a cross-alpha amyloid-like fibril | |
Tayeb-Fligelman, Einav1; Tabachnikov, Orly1; Moshe, Asher1; Goldshmidt-Tran, Orit1; Sawaya, Michael R.2,3; Coquelle, Nicolas4; Colletier, Jacques-Philippe4; Landau, Meytal1 | |
2017-02-24 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 355期号:6327页码:831-833 |
文章类型 | Article |
语种 | 英语 |
国家 | Israel; USA; France |
英文摘要 | Amyloids are ordered protein aggregates, found in all kingdoms of life, and are involved in aggregation diseases as well as in physiological activities. In microbes, functional amyloids are often key virulence determinants, yet the structural basis for their activity remains elusive. We determined the fibril structure and function of the highly toxic, 22-residue phenol-soluble modulin alpha 3 (PSM alpha 3) peptide secreted by Staphylococcus aureus. PSMa3 formed elongated fibrils that shared the morphological and tinctorial characteristics of canonical cross-beta eukaryotic amyloids. However, the crystal structure of full-length PSMa3, solved de novo at 1.45 angstrom resolution, revealed a distinctive "cross-alpha" amyloid-like architecture, in which amphipathic a helices stacked perpendicular to the fibril axis into tight self-associating sheets. The cross-alpha fibrillation of PSM alpha 3 facilitated cytotoxicity, suggesting that this assembly mode underlies function in S. aureus. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000395127600039 |
WOS关键词 | STATE NMR-SPECTROSCOPY ; ATOMIC-RESOLUTION ; FUNCTIONAL AMYLOIDS ; ALZHEIMERS-DISEASE ; PEPTIDE ; SYNUCLEIN ; POLYMORPHISM ; OLIGOMERS ; REPEAT ; CORE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/195506 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Technion Israel Inst Technol, Dept Biol, IL-3200003 Haifa, Israel; 2.Univ Calif Los Angeles, Dept Biol Chem, Dept Chem & Biochem, Los Angeles, CA 90095 USA; 3.Univ Calif Los Angeles, Howard Hughes Med Inst, Los Angeles, CA 90095 USA; 4.Univ Grenoble Alpes, IBS, CEA, CNRS,UMR 5075, F-38044 Grenoble, France |
推荐引用方式 GB/T 7714 | Tayeb-Fligelman, Einav,Tabachnikov, Orly,Moshe, Asher,et al. The cytotoxic Staphylococcus aureus PSM alpha a3 reveals a cross-alpha amyloid-like fibril[J]. SCIENCE,2017,355(6327):831-833. |
APA | Tayeb-Fligelman, Einav.,Tabachnikov, Orly.,Moshe, Asher.,Goldshmidt-Tran, Orit.,Sawaya, Michael R..,...&Landau, Meytal.(2017).The cytotoxic Staphylococcus aureus PSM alpha a3 reveals a cross-alpha amyloid-like fibril.SCIENCE,355(6327),831-833. |
MLA | Tayeb-Fligelman, Einav,et al."The cytotoxic Staphylococcus aureus PSM alpha a3 reveals a cross-alpha amyloid-like fibril".SCIENCE 355.6327(2017):831-833. |
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