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DOI | 10.1126/science.aak9748 |
Molecular and neural basis of contagious itch behavior in mice | |
Yu, Yao-Qing1,2,3; Barry, Devin M.1,2; Hao, Yan1,2,6; Liu, Xue-Ting1,2,7; Chen, Zhou-Feng1,2,4,5 | |
2017-03-10 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 355期号:6329 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Peoples R China |
英文摘要 | Socially contagious itch is ubiquitous in human society, but whether it exists in rodents is unclear. Using a behavioral paradigm that does not entail prior training or reward, we found that mice scratched after observing a conspecific scratching. Molecular mapping showed increased neuronal activity in the suprachiasmatic nucleus (SCN) of the hypothalamus of mice that displayed contagious scratching. Ablation of gastrin-releasing peptide receptor (GRPR) or GRPR neurons in the SCN abolished contagious scratching behavior, which was recapitulated by chemogenetic inhibition of SCN GRP neurons. Activation of SCN GRP/GRPR neurons evoked scratching behavior. These data demonstrate that GRP-GRPR signaling is necessary and sufficient for transmitting contagious itch information in the SCN. The findings may have implications for our understanding of neural circuits that control socially contagious behaviors. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000396348900044 |
WOS关键词 | GASTRIN-RELEASING-PEPTIDE ; SUPRACHIASMATIC NUCLEUS ; SENSATION ; RECEPTOR ; RHYTHMS ; EMPATHY ; NEURONS ; MOUSE ; LIGHT |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/195577 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Washington Univ, Sch Med, Ctr Study Itch, St Louis, MO 63110 USA; 2.Washington Univ, Sch Med, Dept Anesthesiol, St Louis, MO 63110 USA; 3.Fourth Mil Med Univ, Tangdu Hosp, Inst Biomed Sci Pain, Xian 710038, Shaanxi, Peoples R China; 4.Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA; 5.Washington Univ, Sch Med, Dept Dev Biol, St Louis, MO 63110 USA; 6.Huazhong Univ Sci & Technol, Dept Pediat, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China; 7.Guangzhou Med Univ, Affiliated Hosp 2, Guangdong Prov Key Lab Allergy & Clin Immunol, State Key Lab Resp Dis, Guangzhou 510260, Guangdong, Peoples R China |
推荐引用方式 GB/T 7714 | Yu, Yao-Qing,Barry, Devin M.,Hao, Yan,et al. Molecular and neural basis of contagious itch behavior in mice[J]. SCIENCE,2017,355(6329). |
APA | Yu, Yao-Qing,Barry, Devin M.,Hao, Yan,Liu, Xue-Ting,&Chen, Zhou-Feng.(2017).Molecular and neural basis of contagious itch behavior in mice.SCIENCE,355(6329). |
MLA | Yu, Yao-Qing,et al."Molecular and neural basis of contagious itch behavior in mice".SCIENCE 355.6329(2017). |
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