A key malaria metabolite modulates vector blood seeking, feeding, and susceptibility to infection

doi:10.1126/science.aah4563

GSTDTAP > 地球科学

DOI	10.1126/science.aah4563
	A key malaria metabolite modulates vector blood seeking, feeding, and susceptibility to infection
	Emami, S. Noushin 1,2; Lindberg, Bo G.1; Hua, Susanna 1; Hill, Sharon R.2; Mozuraitis, Raimondas 3,4; Lehmann, Philipp 5; Birgersson, Goran 2; Borg-Karlson, Anna-Karin 3; Ignell, Rickard 2; Faye, Ingrid 1
	2017-03-10
发表期刊	SCIENCE
ISSN	0036-8075
EISSN	1095-9203
出版年	2017
卷号	355 期号:6329 页码:1076-1080
文章类型	Article
语种	英语
国家	Sweden; Lithuania
英文摘要	Malaria infection renders humans more attractive to Anopheles gambiae sensu lato mosquitoes than uninfected people. The mechanisms remain unknown. We found that an isoprenoid precursor produced by Plasmodium falciparum, (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP), affects A. gambiae s. l. blood meal seeking and feeding behaviors as well as susceptibility to infection. HMBPP acts indirectly by triggering human red blood cells to increase the release of CO2, aldehydes, and monoterpenes, which together enhance vector attraction and stimulate vector feeding. When offered in a blood meal, HMBPP modulates neural, antimalarial, and oogenic gene transcription without affecting mosquito survival or fecundity; in a P. falciparum-infected blood meal, sporogony is increased.
领域	地球科学 ; 气候变化 ; 资源环境
收录类别	SCI-E
WOS记录号	WOS:000396348900045
WOS关键词	PLASMODIUM-FALCIPARUM ; ATTRACTIVENESS ; INCREASES ; MANIPULATION ; MEMORY
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
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引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/195580
专题	地球科学资源环境科学气候变化
作者单位	1.Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, SE-10691 Stockholm, Sweden; 2.SLU, Dept Plant Protect Biol, Unit Chem Ecol, SE-23053 Alnarp, Sweden; 3.Royal Inst Technol, Dept Chem, Organ Chem, SE-10044 Stockholm, Sweden; 4.Nat Res Ctr, Inst Ecol, Lab Chem & Behav Ecol, LT-08412 Vilnius, Lithuania; 5.Stockholm Univ, Dept Zool, SE-10691 Stockholm, Sweden
推荐引用方式 GB/T 7714	Emami, S. Noushin,Lindberg, Bo G.,Hua, Susanna,et al. A key malaria metabolite modulates vector blood seeking, feeding, and susceptibility to infection[J]. SCIENCE,2017,355(6329):1076-1080.
APA	Emami, S. Noushin.,Lindberg, Bo G..,Hua, Susanna.,Hill, Sharon R..,Mozuraitis, Raimondas.,...&Faye, Ingrid.(2017).A key malaria metabolite modulates vector blood seeking, feeding, and susceptibility to infection.SCIENCE,355(6329),1076-1080.
MLA	Emami, S. Noushin,et al."A key malaria metabolite modulates vector blood seeking, feeding, and susceptibility to infection".SCIENCE 355.6329(2017):1076-1080.