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DOI | 10.1126/science.aag2516 |
Structural basis of the day-night transition in a bacterial circadian clock | |
Tseng, Roger1; Goularte, Nicolette F.2; Chavan, Archana3; Luu, Jansen2; Cohen, Susan E.4; Chang, Yong-Gang3; Heisler, Joel6; Li, Sheng7; Michael, Alicia K.2; Tripathi, Sarvind2; Golden, Susan S.4,5; LiWang, Andy1,3,4,6,8; Partch, Carrie L.2,4 | |
2017-03-17 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 355期号:6330页码:1174-1180 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Circadian clocks are ubiquitous timing systems that induce rhythms of biological activities in synchrony with night and day. In cyanobacteria, timing is generated by a posttranslational clock consisting of KaiA, KaiB, and KaiC proteins and a set of output signaling proteins, SasA and CikA, which transduce this rhythm to control gene expression. Here, we describe crystal and nuclear magnetic resonance structures of KaiB-KaiC, KaiA-KaiB-KaiC, and CikA-KaiB complexes. They reveal how the metamorphic properties of KaiB, a protein that adopts two distinct folds, and the post-adenosine triphosphate hydrolysis state of KaiC create a hub around which nighttime signaling events revolve, including inactivation of KaiA and reciprocal regulation of the mutually antagonistic signaling proteins, SasA and CikA. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000396351200036 |
WOS关键词 | KAIC PHOSPHORYLATION ; PROTEIN KAIA ; SYNECHOCOCCUS-ELONGATUS ; GENE-EXPRESSION ; COMPLEX ; OSCILLATOR ; RHYTHMS ; DOMAIN ; TIME ; MECHANISMS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/195640 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Calif, Quantitat & Syst Biol, Merced, CA 95343 USA; 2.Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA; 3.Univ Calif, Sch Nat Sci, Merced, CA 95343 USA; 4.Univ Calif San Diego, Ctr Circadian Biol, La Jolla, CA 92093 USA; 5.Univ Calif San Diego, Dept Biol Sci, La Jolla, CA 92093 USA; 6.Univ Calif, Chem & Chem Biol, Merced, CA 95343 USA; 7.Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA; 8.Univ Calif, Hlth Sci Res Inst, Merced, CA 95343 USA |
推荐引用方式 GB/T 7714 | Tseng, Roger,Goularte, Nicolette F.,Chavan, Archana,et al. Structural basis of the day-night transition in a bacterial circadian clock[J]. SCIENCE,2017,355(6330):1174-1180. |
APA | Tseng, Roger.,Goularte, Nicolette F..,Chavan, Archana.,Luu, Jansen.,Cohen, Susan E..,...&Partch, Carrie L..(2017).Structural basis of the day-night transition in a bacterial circadian clock.SCIENCE,355(6330),1174-1180. |
MLA | Tseng, Roger,et al."Structural basis of the day-night transition in a bacterial circadian clock".SCIENCE 355.6330(2017):1174-1180. |
条目包含的文件 | 条目无相关文件。 |
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