Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aag1006 |
Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420 | |
Blondiaux, Nicolas1; Moune, Martin1; Desroses, Matthieu2,3; Frita, Rosangela1; Flipo, Marion2; Mathys, Vanessa4; Soetaert, Karine4; Kiass, Mehdi4; Delorme, Vincent1,5; Djaout, Kamel1; Trebosc, Vincent6,7; Kemmer, Christian6; Wintjens, Rene8; Wohlkonig, Alexandre9,10; Antoine, Rudy1; Huot, Ludovic1; Hot, David1; Coscolla, Mireia11,12; Feldmann, Julia11,12; Gagneux, Sebastien11,12; Locht, Camille1; Brodin, Priscille1; Gitzinger, Marc6; Deprez, Benoit2; Willand, Nicolas2; Baulard, Alain R.1 | |
2017-03-17 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 355期号:6330页码:1206-1211 |
文章类型 | Article |
语种 | 英语 |
国家 | France; Sweden; Belgium; South Korea; Switzerland |
英文摘要 | Antibiotic resistance is one of the biggest threats to human health globally. Alarmingly, multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis have now spread worldwide. Some key antituberculosis antibiotics are prodrugs, for which resistance mechanisms are mainly driven by mutations in the bacterial enzymatic pathway required for their bioactivation. We have developed drug-like molecules that activate a cryptic alternative bioactivation pathway of ethionamide in M. tuberculosis, circumventing the classic activation pathway in which resistance mutations have now been observed. The first-of-its-kind molecule, named SMARt-420 (Small Molecule Aborting Resistance), not only fully reverses ethionamide-acquired resistance and clears ethionamide-resistant infection in mice, it also increases the basal sensitivity of bacteria to ethionamide. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000396351200044 |
WOS关键词 | 1,2,4-OXADIAZOLE ETHR INHIBITORS ; ETHIONAMIDE BOOSTERS ; DRUG ETHIONAMIDE ; ACTIVATION ; GENE ; RECOGNITION ; MECHANISMS ; INDUCTION ; REPRESSOR ; FAMILY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/195641 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Lille, Inst Pasteur Lille, CIIL, CNRS,Inserm,CHU Lille,U1019,UMR8204, F-59000 Lille, France; 2.Univ Lille, Inst Pasteur Lille, Drugs & Mol Living Syst, Inserm,U1177, F-59000 Lille, France; 3.Karolinska Inst, Div Translat Med & Chem Biol, Sci Life Lab, Dept Med Biochem & Biophys, Stockholm, Sweden; 4.Sci Inst Publ Hlth WIV ISP, Natl Reference Ctr TB & Mycobacteria, Bacterial Dis Serv, Operat Direct Communicable & Infect Dis, Brussels, Belgium; 5.Inst Pasteur Korea, TB Res Lab, Seoul, South Korea; 6.Bioversys AG, Hochbergerstr 60C, CH-4057 Basel, Switzerland; 7.Univ Basel, Biozentrum, Basel, Switzerland; 8.Univ Libre Bruxelles, Lab Biopolymeres Nanomat Supramol, Brussels, Belgium; 9.VIB, VIB Ctr Struct Biol, Pl Laan 2, B-1050 Brussels, Belgium; 10.VUB, Struct Biol Brussels, Pl Laan 2, B-1050 Brussels, Belgium; 11.Swiss Trop & Publ Hlth Inst, Basel, Switzerland; 12.Univ Basel, Basel, Switzerland |
推荐引用方式 GB/T 7714 | Blondiaux, Nicolas,Moune, Martin,Desroses, Matthieu,et al. Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420[J]. SCIENCE,2017,355(6330):1206-1211. |
APA | Blondiaux, Nicolas.,Moune, Martin.,Desroses, Matthieu.,Frita, Rosangela.,Flipo, Marion.,...&Baulard, Alain R..(2017).Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420.SCIENCE,355(6330),1206-1211. |
MLA | Blondiaux, Nicolas,et al."Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420".SCIENCE 355.6330(2017):1206-1211. |
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