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DOI | 10.1126/science.aaf8451 |
Inflammation boosts bacteriophage transfer between Salmonella spp. | |
Diard, Mederic1; Bakkeren, Erik1; Cornuault, Jeffrey K.2; Moor, Kathrin1; Hausmann, Annika1; Sellin, Mikael E.1,7; Loverdo, Claude3; Aertsen, Abram4; Ackermann, Martin5,6; De Paepe, Marianne2; Slack, Emma1; Hardt, Wolf-Dietrich1 | |
2017-03-17 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 355期号:6330页码:1211-1215 |
文章类型 | Article |
语种 | 英语 |
国家 | Switzerland; France; Belgium; Sweden |
英文摘要 | Bacteriophage transfer (lysogenic conversion) promotes bacterial virulence evolution. There is limited understanding of the factors that determine lysogenic conversion dynamics within infected hosts. Amurine Salmonella Typhimurium (S.Tm) diarrhea model was used to study the transfer of SopEF, a prophage from S.Tm SL1344, to S.Tm ATCC14028S. Gut inflammation and enteric disease triggered >55% lysogenic conversion of ATCC14028S within 3 days. Without inflammation, SopEF transfer was reduced by up to 10(5)-fold. This was because inflammation (e.g., reactive oxygen species, reactive nitrogen species, hypochlorite) triggers the bacterial SOS response, boosts expression of the phage antirepressor Tum, and thereby promotes free phage production and subsequent transfer. Mucosal vaccination prevented a dense intestinal S.Tm population from inducing inflammation and consequently abolished SopEF transfer. Vaccination may be a general strategy for blocking pathogen evolution that requires disease-driven transfer of temperate bacteriophages. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000396351200045 |
WOS关键词 | LYSOGENIC CONVERSION ; FELS-2 PROPHAGE ; COLIPHAGE 186 ; PHAGE ; TYPHIMURIUM ; PROTEIN ; TOXIN ; GENE ; SOPE ; PHENOTYPE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/195642 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Swiss Fed Inst Technol, Inst Microbiol, Zurich, Switzerland; 2.Univ Paris Saclay, AgroParisTech, INRA, Micalis Inst, F-78350 Jouy En Josas, France; 3.UPMC, CNRS, Lab Jean Perrin, UMR 8237, F-75005 Paris, France; 4.Katholieke Univ Leuven, Dept Microbial & Mol Syst, Leuven, Belgium; 5.Swiss Fed Inst Technol, Dept Environm Syst Sci, Zurich, Switzerland; 6.Eawag, Dept Environm Microbiol, Dubendorf, Switzerland; 7.Uppsala Univ, Dept Med Biochem & Microbiol, Sci Life Lab, Uppsala, Sweden |
推荐引用方式 GB/T 7714 | Diard, Mederic,Bakkeren, Erik,Cornuault, Jeffrey K.,et al. Inflammation boosts bacteriophage transfer between Salmonella spp.[J]. SCIENCE,2017,355(6330):1211-1215. |
APA | Diard, Mederic.,Bakkeren, Erik.,Cornuault, Jeffrey K..,Moor, Kathrin.,Hausmann, Annika.,...&Hardt, Wolf-Dietrich.(2017).Inflammation boosts bacteriophage transfer between Salmonella spp..SCIENCE,355(6330),1211-1215. |
MLA | Diard, Mederic,et al."Inflammation boosts bacteriophage transfer between Salmonella spp.".SCIENCE 355.6330(2017):1211-1215. |
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