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DOI | 10.1126/science.aal5056 |
CRISPR-Cas: Adapting to change | |
Jackson, Simon A.1; McKenzie, Rebecca E.2; Fagerlund, Robert D.1; Kieper, Sebastian N.2; Fineran, Peter C.1,3; Brouns, Stan J. J.2,4 | |
2017-04-07 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 356期号:6333 |
文章类型 | Review |
语种 | 英语 |
国家 | New Zealand; Netherlands |
英文摘要 | Bacteria and archaea are engaged in a constant arms race to defend against the ever-present threats of viruses and invasion by mobile genetic elements. The most flexible weapons in the prokaryotic defense arsenal are the CRISPR-Cas adaptive immune systems. These systems are capable of selective identification and neutralization of foreign DNA and/or RNA. CRISPR-Cas systems rely on stored genetic memories to facilitate target recognition. Thus, to keep pace with a changing pool of hostile invaders, the CRISPR memory banks must be regularly updated with new information through a process termed CRISPR adaptation. In this Review, we outline the recent advances in our understanding of the molecular mechanisms governing CRISPR adaptation. Specifically, the conserved protein machinery Cas1-Cas2 is the cornerstone of adaptive immunity in a range of diverse CRISPR-Cas systems. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000398689100029 |
WOS关键词 | QUORUM SENSING CONTROLS ; SPACER ACQUISITION ; ESCHERICHIA-COLI ; IMMUNE-SYSTEM ; FOREIGN DNA ; STREPTOCOCCUS-THERMOPHILUS ; HALOARCULA-HISPANICA ; BACTERIAL IMMUNITY ; PROTEIN COMPLEX ; HOST FACTOR |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/195765 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Otago, Dept Microbiol & Immunol, POB 56, Dunedin 9054, New Zealand; 2.Delft Univ Technol, Kavli Inst Nanosci, Dept Bionanosci, Maasweg 9, NL-2629 HZ Delft, Netherlands; 3.Univ Otago, Bioprotect Res Ctr, POB 56, Dunedin 9054, New Zealand; 4.Wageningen Univ, Microbiol Lab, Wageningen, Netherlands |
推荐引用方式 GB/T 7714 | Jackson, Simon A.,McKenzie, Rebecca E.,Fagerlund, Robert D.,et al. CRISPR-Cas: Adapting to change[J]. SCIENCE,2017,356(6333). |
APA | Jackson, Simon A.,McKenzie, Rebecca E.,Fagerlund, Robert D.,Kieper, Sebastian N.,Fineran, Peter C.,&Brouns, Stan J. J..(2017).CRISPR-Cas: Adapting to change.SCIENCE,356(6333). |
MLA | Jackson, Simon A.,et al."CRISPR-Cas: Adapting to change".SCIENCE 356.6333(2017). |
条目包含的文件 | 条目无相关文件。 |
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