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DOI | 10.1126/science.aal3485 |
Stromal Gli2 activity coordinates a niche signaling program for mammary epithelial stem cells | |
Zhao, Chen1,2; Cai, Shang1; Shin, Kunyoo1,2,3; Lim, Agnes1,4; Kalisky, Tomer5,6; Lu, Wan-Jin1,2; Clarke, Michael F.1; Beachy, Philip A.1,2,4,7 | |
2017-04-21 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 356期号:6335 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; South Korea; Israel |
英文摘要 | The stem cell niche is a complex local signaling microenvironment that sustains stem cell activity during organ maintenance and regeneration. The mammary gland niche must support its associated stem cells while also responding to systemic hormonal regulation that triggers pubertal changes. We find that Gli2, the major Hedgehog pathway transcriptional effector, acts within mouse mammary stromal cells to direct a hormone-responsive niche signaling program by activating expression of factors that regulate epithelial stem cells as well as receptors for the mammatrophic hormones estrogen and growth hormone. Whereas prior studies implicate stem cell defects in human disease, this work shows that niche dysfunction may also cause disease, with possible relevance for human disorders and in particular the breast growth pathogenesis associated with combined pituitary hormone deficiency. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000399540100053 |
WOS关键词 | GROWTH-FACTOR-I ; GLAND DEVELOPMENT ; TRANSCRIPTION FACTOR ; HORMONE DEFICIENCY ; IGF-I ; MOUSE ; HEDGEHOG ; DIFFERENTIATION ; EXPRESSION ; RECEPTOR |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/195859 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Stanford Univ, Sch Med, Inst Stem Cell Biol & Regenerat Med, Stanford, CA 94305 USA; 2.Stanford Univ, Sch Med, Dept Biochem, Stanford, CA 94305 USA; 3.Pohang Univ Sci & Technol, Dept Life Sci, Pohang 37673, Gyumgbuk, South Korea; 4.Stanford Univ, Sch Med, Dept Dev Biol, Stanford, CA 94305 USA; 5.Bar Ilan Univ, Fac Engn, IL-52900 Ramat Gan, Israel; 6.Bar Ilan Univ, Inst Nanotechnol & Adv Mat, IL-52900 Ramat Gan, Israel; 7.Stanford Univ, Sch Med, Howard Hughes Med Inst, Stanford, CA 94305 USA |
推荐引用方式 GB/T 7714 | Zhao, Chen,Cai, Shang,Shin, Kunyoo,et al. Stromal Gli2 activity coordinates a niche signaling program for mammary epithelial stem cells[J]. SCIENCE,2017,356(6335). |
APA | Zhao, Chen.,Cai, Shang.,Shin, Kunyoo.,Lim, Agnes.,Kalisky, Tomer.,...&Beachy, Philip A..(2017).Stromal Gli2 activity coordinates a niche signaling program for mammary epithelial stem cells.SCIENCE,356(6335). |
MLA | Zhao, Chen,et al."Stromal Gli2 activity coordinates a niche signaling program for mammary epithelial stem cells".SCIENCE 356.6335(2017). |
条目包含的文件 | 条目无相关文件。 |
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