Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aah6412 |
Transgenerational transmission of environmental information in C-elegans | |
Klosin, Adam1,2; Casas, Eduard3; Hidalgo-Carcedo, Cristina1,2; Vavouri, Tanya3,4; Lehner, Ben1,2,5 | |
2017-04-21 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 356期号:6335页码:316-319 |
文章类型 | Article |
语种 | 英语 |
国家 | Spain |
英文摘要 | The environment experienced by an animal can sometimes influence gene expression for one or a few subsequent generations. Here, we report the observation that a temperature-induced change in expression from a Caenorhabditis elegans heterochromatic gene array can endure for at least 14 generations. Inheritance is primarily in cis with the locus, occurs through both oocytes and sperm, and is associated with altered trimethylation of histone H3 lysine 9 (H3K9me3) before the onset of zygotic transcription. Expression profiling reveals that temperature-induced expression from endogenous repressed repeats can also be inherited for multiple generations. Long-lasting epigenetic memory of environmental change is therefore possible in this animal. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000399540100062 |
WOS关键词 | IN-UTERO UNDERNUTRITION ; CAENORHABDITIS-ELEGANS ; EPIGENETIC INHERITANCE ; GERMLINE ; METHYLATION ; OBESITY ; DIET ; STARVATION ; RESISTANCE ; MAMMALS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/195866 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.European Mol Biol Org, EMBL CRG Syst Biol Unit, Ctr Genom Regulat, Barcelona 08003, Spain; 2.Univ Pompeu Fabra, Barcelona 08003, Spain; 3.Inst Germans Trias & Pujol, Program Predict & Personalized Med Canc, Campus Can Ruti, Barcelona 08916, Spain; 4.Josep Carreras Leukaemia Res Inst, Barcelona 08916, Spain; 5.Inst Catalana Recerca & Estudis Avancats, Barcelona 08010, Spain |
推荐引用方式 GB/T 7714 | Klosin, Adam,Casas, Eduard,Hidalgo-Carcedo, Cristina,et al. Transgenerational transmission of environmental information in C-elegans[J]. SCIENCE,2017,356(6335):316-319. |
APA | Klosin, Adam,Casas, Eduard,Hidalgo-Carcedo, Cristina,Vavouri, Tanya,&Lehner, Ben.(2017).Transgenerational transmission of environmental information in C-elegans.SCIENCE,356(6335),316-319. |
MLA | Klosin, Adam,et al."Transgenerational transmission of environmental information in C-elegans".SCIENCE 356.6335(2017):316-319. |
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