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DOI | 10.1126/science.aag2029 |
Neonatal acquisition of Clostridia species protects against colonization by bacterial pathogens | |
Kim, Yun-Gi1,2,11; Sakamoto, Kei1,2; Seo, Sang-Uk1,2,12; Pickard, Joseph M.1,2; Gillilland, Merritt G., III3; Pudlo, Nicholas A.4; Hoostal, Matthew3; Li, Xue3; Wang, Thomas D.5,6; Feehley, Taylor7,8; Stefka, Andrew T.7,8; Schmidt, Thomas M.3,4; Martens, Eric C.4; Fukuda, Shinji9,10; Inohara, Naohiro1; Nagler, Cathryn R.7,8; Nunez, Gabriel1,2 | |
2017-04-21 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 356期号:6335页码:312-315 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Japan; South Korea |
英文摘要 | The high susceptibility of neonates to infections has been assumed to be due to immaturity of the immune system, but the mechanism remains unclear. By colonizing adult germ-free mice with the cecal contents of neonatal and adult mice, we show that the neonatal microbiota is unable to prevent colonization by two bacterial pathogens that cause mortality in neonates. The lack of colonization resistance occurred when Clostridiales were absent in the neonatal microbiota. Administration of Clostridiales, but not Bacteroidales, protected neonatal mice from pathogen infection and abrogated intestinal pathology upon pathogen challenge. Depletion of Clostridiales also abolished colonization resistance in adult mice. The neonatal bacteria enhanced the ability of protective Clostridiales to colonize the gut. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000399540100061 |
WOS关键词 | GUT MICROBIOTA ; INFECTION ; RESPONSES ; IMMUNITY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/195868 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Michigan, Dept Pathol, Med Sch, Ann Arbor, MI 48109 USA; 2.Univ Michigan, Comprehens Canc Ctr, Med Sch, Ann Arbor, MI 48109 USA; 3.Univ Michigan, Dept Internal Med, Med Sch, Ann Arbor, MI 48109 USA; 4.Univ Michigan, Dept Microbiol & Immunol, Med Sch, Ann Arbor, MI 48109 USA; 5.Univ Michigan, Dept Biomed Engn, Med Sch, Ann Arbor, MI 48109 USA; 6.Univ Michigan, Dept Mech Engn, Med Sch, Ann Arbor, MI 48109 USA; 7.Univ Chicago, Dept Pathol, Chicago, IL 60637 USA; 8.Univ Chicago, Comm Immunol, Chicago, IL 60637 USA; 9.Keio Univ, Inst Adv Biosci, Yamagata, Japan; 10.Japan Sci & Technol Agcy, PRESTO, Kawaguchi, Saitama 3320012, Japan; 11.Keio Univ, Div Biochem, Fac Pharm, Minato Ku, 1-5-30 Shibakoen, Tokyo 1058512, Japan; 12.Seoul Natl Univ, Wide River Inst Immunol, Coll Med, Dept Biomed Sci, Seoul 03080, South Korea |
推荐引用方式 GB/T 7714 | Kim, Yun-Gi,Sakamoto, Kei,Seo, Sang-Uk,et al. Neonatal acquisition of Clostridia species protects against colonization by bacterial pathogens[J]. SCIENCE,2017,356(6335):312-315. |
APA | Kim, Yun-Gi.,Sakamoto, Kei.,Seo, Sang-Uk.,Pickard, Joseph M..,Gillilland, Merritt G., III.,...&Nunez, Gabriel.(2017).Neonatal acquisition of Clostridia species protects against colonization by bacterial pathogens.SCIENCE,356(6335),312-315. |
MLA | Kim, Yun-Gi,et al."Neonatal acquisition of Clostridia species protects against colonization by bacterial pathogens".SCIENCE 356.6335(2017):312-315. |
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