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DOI | 10.1126/science.aaf4762 |
Biased partitioning of the multidrug efflux pump AcrAB-TolC underlies long-lived phenotypic heterogeneity | |
Bergmiller, Tobias1; Andersson, Anna M. C.1; Tomasek, Kathrin1; Balleza, Enrique2,3; Kiviet, Daniel J.4,5; Hauschild, Robert1; Tkacik, Gasper1; Guet, Calin C.1 | |
2017-04-21 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 356期号:6335页码:309-311 |
文章类型 | Article |
语种 | 英语 |
国家 | Austria; USA; Switzerland |
英文摘要 | The molecular mechanisms underlying phenotypic variation in isogenic bacterial populations remain poorly understood. We report that AcrAB-TolC, the main multidrug efflux pump of Escherichia coli, exhibits a strong partitioning bias for old cell poles by a segregation mechanism that is mediated by ternary AcrAB-TolC complex formation. Mother cells inheriting old poles are phenotypically distinct and display increased drug efflux activity relative to daughters. Consequently, we find systematic and long-lived growth differences between mother and daughter cells in the presence of subinhibitory drug concentrations. A simple model for biased partitioning predicts a population structure of long-lived and highly heterogeneous phenotypes. This straightforward mechanism of generating sustained growth rate differences at subinhibitory antibiotic concentrations has implications for understanding the emergence of multidrug resistance in bacteria. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000399540100060 |
WOS关键词 | OUTER-MEMBRANE PROTEINS ; ESCHERICHIA-COLI ; ANTIBIOTIC-RESISTANCE ; BACTERIA ; AMPLIFICATION ; EVOLUTION ; GENES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/195870 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.IST Austria, A-3400 Klosterneuburg, Austria; 2.Harvard Univ, Fac Arts & Sci, Ctr Syst Biol, Cambridge, MA 02138 USA; 3.Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA; 4.Swiss Fed Inst Technol, Swiss Fed Inst Technol, Dept Environm Syst Sci, CH-8092 Zurich, Switzerland; 5.Swiss Fed Inst Aquat Sci & Technol, Dept Environm Microbiol, Eawag, CH-8600 Dubendorf, Switzerland |
推荐引用方式 GB/T 7714 | Bergmiller, Tobias,Andersson, Anna M. C.,Tomasek, Kathrin,et al. Biased partitioning of the multidrug efflux pump AcrAB-TolC underlies long-lived phenotypic heterogeneity[J]. SCIENCE,2017,356(6335):309-311. |
APA | Bergmiller, Tobias.,Andersson, Anna M. C..,Tomasek, Kathrin.,Balleza, Enrique.,Kiviet, Daniel J..,...&Guet, Calin C..(2017).Biased partitioning of the multidrug efflux pump AcrAB-TolC underlies long-lived phenotypic heterogeneity.SCIENCE,356(6335),309-311. |
MLA | Bergmiller, Tobias,et al."Biased partitioning of the multidrug efflux pump AcrAB-TolC underlies long-lived phenotypic heterogeneity".SCIENCE 356.6335(2017):309-311. |
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