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DOI | 10.1126/science.aal3245 |
Branch-specific plasticity of a bifunctional dopamine circuit encodes protein hunger | |
Liu, Qili1; Tabuchi, Masashi1; Liu, Sha1; Kodama, Lay1; Horiuchi, Wakako1; Daniels, Jay1; Chiu, Lucinda1; Baldoni, Daniel1; Wu, Mark N.1,2 | |
2017-05-05 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 356期号:6337页码:534-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Free-living animals must not only regulate the amount of food they consume but also choose which types of food to ingest. The shifting of food preference driven by nutrient-specific hunger can be essential for survival, yet little is known about the underlying mechanisms. We identified a dopamine circuit that encodes protein-specific hunger in Drosophila. The activity of these neurons increased after substantial protein deprivation. Activation of this circuit simultaneously promoted protein intake and restricted sugar consumption, via signaling to distinct downstream neurons. Protein starvation triggered branch-specific plastic changes in these dopaminergic neurons, thus enabling sustained protein consumption. These studies reveal a crucial circuit mechanism by which animals adjust their dietary strategy to maintain protein homeostasis. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000400545700037 |
WOS关键词 | AMINO-ACIDS ; DROSOPHILA ; NEURONS ; MELANOGASTER ; APPETITE ; MARKER ; RATS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/195981 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Johns Hopkins Univ, Dept Neurol, Baltimore, MD 21205 USA; 2.Johns Hopkins Univ, Dept Neurosci, Baltimore, MD 21205 USA |
推荐引用方式 GB/T 7714 | Liu, Qili,Tabuchi, Masashi,Liu, Sha,et al. Branch-specific plasticity of a bifunctional dopamine circuit encodes protein hunger[J]. SCIENCE,2017,356(6337):534-+. |
APA | Liu, Qili.,Tabuchi, Masashi.,Liu, Sha.,Kodama, Lay.,Horiuchi, Wakako.,...&Wu, Mark N..(2017).Branch-specific plasticity of a bifunctional dopamine circuit encodes protein hunger.SCIENCE,356(6337),534-+. |
MLA | Liu, Qili,et al."Branch-specific plasticity of a bifunctional dopamine circuit encodes protein hunger".SCIENCE 356.6337(2017):534-+. |
条目包含的文件 | 条目无相关文件。 |
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