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DOI | 10.1126/science.aam7511 |
Lineage-dependent spatial and functional organization of the mammalian enteric nervous system | |
Lasrado, Reena1; Boesmans, Werend1,2; Kleinjung, Jens1; Pin, Carmen3; Bell, Donald1; Bhaw, Leena1,7; McCallum, Sarah1; Zong, Hui4,8; Luo, Liqun4; Clevers, Hans5,6; Berghe, Pieter Vanden2; Pachnis, Vassilis1 | |
2017-05-19 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 356期号:6339页码:722-726 |
文章类型 | Article |
语种 | 英语 |
国家 | England; Belgium; USA; Netherlands |
英文摘要 | The enteric nervous system (ENS) is essential for digestive function and gut homeostasis. Here we show that the amorphous neuroglia networks of the mouse ENS are composed of overlapping clonal units founded by postmigratory neural crest-derived progenitors. The spatial configuration of ENS clones depends on proliferation-driven local interactions of ENS progenitors with lineally unrelated neuroectodermal cells, the ordered colonization of the serosa-mucosa axis by clonal descendants, and gut expansion. Single-cell transcriptomics and mutagenesis analysis delineated dynamic molecular states of ENS progenitors and identified RET as a regulator of neurogenic commitment. Clonally related enteric neurons exhibit synchronous activity in response to network stimulation. Thus, lineage relationships underpin the organization of the peripheral nervous system. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000401508400040 |
WOS关键词 | NEURAL CREST CELLS ; GLIAL-CELLS ; STEM-CELLS ; EXPRESSION ; INTESTINE ; MARKERS ; KIDNEY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196082 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Francis Crick Inst, 1 Midland Rd, London NW1 1AT, England; 2.Univ Leuven, Dept Clin & Expt Med, Lab Enter Neurosci LENS, Translat Res GastroIntestinal Disorders TARGID, Leuven, Belgium; 3.Inst Food Res, Norwich NR4 7UA, Norfolk, England; 4.Stanford Univ, Howard Hughes Med Inst, Dept Biol, Stanford, CA 94305 USA; 5.KNAW Royal Netherlands Acad Arts & Sci, Hubrecht Inst, NL-3584 CT Utrecht, Netherlands; 6.Univ Med Ctr Utrecht, NL-3584 CT Utrecht, Netherlands; 7.Imperial Coll London, Biomed Res Ctr, Genom Lab, Room 4N5,Commonwealth Bldg,Du Cane Rd, London W12 0NN, England; 8.Univ Virginia, Sch Med, Dept Microbiol Immunol & Canc Biol, Charlottesville, VA 22908 USA |
推荐引用方式 GB/T 7714 | Lasrado, Reena,Boesmans, Werend,Kleinjung, Jens,et al. Lineage-dependent spatial and functional organization of the mammalian enteric nervous system[J]. SCIENCE,2017,356(6339):722-726. |
APA | Lasrado, Reena.,Boesmans, Werend.,Kleinjung, Jens.,Pin, Carmen.,Bell, Donald.,...&Pachnis, Vassilis.(2017).Lineage-dependent spatial and functional organization of the mammalian enteric nervous system.SCIENCE,356(6339),722-726. |
MLA | Lasrado, Reena,et al."Lineage-dependent spatial and functional organization of the mammalian enteric nervous system".SCIENCE 356.6339(2017):722-726. |
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