Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aal3096 |
Blocking promiscuous activation at cryptic promoters directs cell type-specific gene expression | |
Kim, Jongmin1,2; Lu, Chenggang2; Srinivasan, Shrividhya2; Awe, Stephan3; Brehm, Alexander3; Fuller, Margaret T.2,4 | |
2017-05-19 | |
发表期刊 | SCIENCE
![]() |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 356期号:6339页码:717-721 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Germany |
英文摘要 | To selectively express cell type-specific transcripts during development, it is critical to maintain genes required for other lineages in a silent state. Here, we show in the Drosophila male germline stem cell lineage that a spermatocyte-specific zinc finger protein, Kumgang (Kmg), working with the chromatin remodeler dMi-2 prevents transcription of genes normally expressed only in somatic lineages. By blocking transcription from normally cryptic promoters, Kmg restricts activation by Aly, a component of the testis-meiotic arrest complex, to transcripts for male germ cell differentiation. Our results suggest that as new regions of the genome become open for transcription during terminal differentiation, blocking the action of a promiscuous activator on cryptic promoters is a critical mechanism for specifying precise gene activation. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000401508400039 |
WOS关键词 | TERMINAL DIFFERENTIATION GENES ; BAG-OF-MARBLES ; DROSOPHILA-MELANOGASTER ; TRANSCRIPTION ; LINEAGE ; PROTEIN ; GENOME ; IKAROS ; LEUKEMOGENESIS ; LOCALIZATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196086 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Stanford Univ, Sch Med, Dept Chem & Syst Biol, Stanford, CA 94305 USA; 2.Stanford Univ, Dept Dev Biol, Sch Med, Stanford, CA 94305 USA; 3.Philipps Univ Marburg, Inst Mol Biol & Tumorforsch, Marburg, Germany; 4.Stanford Univ, Dept Genet, Sch Med, Stanford, CA 94305 USA |
推荐引用方式 GB/T 7714 | Kim, Jongmin,Lu, Chenggang,Srinivasan, Shrividhya,et al. Blocking promiscuous activation at cryptic promoters directs cell type-specific gene expression[J]. SCIENCE,2017,356(6339):717-721. |
APA | Kim, Jongmin,Lu, Chenggang,Srinivasan, Shrividhya,Awe, Stephan,Brehm, Alexander,&Fuller, Margaret T..(2017).Blocking promiscuous activation at cryptic promoters directs cell type-specific gene expression.SCIENCE,356(6339),717-721. |
MLA | Kim, Jongmin,et al."Blocking promiscuous activation at cryptic promoters directs cell type-specific gene expression".SCIENCE 356.6339(2017):717-721. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论