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DOI | 10.1126/science.aaf6846 |
ATP as a biological hydrotrope | |
Patel, Avinash1; Malinovska, Liliana1; Saha, Shambaditya1; Wang, Jie1; Alberti, Simon1; Krishnan, Yamuna2,3; Hyman, Anthony A.1 | |
2017-05-19 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 356期号:6339页码:753-756 |
文章类型 | Article |
语种 | 英语 |
国家 | Germany; USA |
英文摘要 | Hydrotropes are small molecules that solubilize hydrophobic molecules in aqueous solutions. Typically, hydrotropes are amphiphilic molecules and differ from classical surfactants in that they have low cooperativity of aggregation and work at molar concentrations. Here, we show that adenosine triphosphate (ATP) has properties of a biological hydrotrope. It can both prevent the formation of and dissolve previously formed protein aggregates. This chemical property is manifested at physiological concentrations between 5 and 10 millimolar. Therefore, in addition to being an energy source for biological reactions, for which micromolar concentrations are sufficient, we propose that millimolar concentrations of ATP may act to keep proteins soluble. This may in part explain why ATP is maintained in such high concentrations in cells. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000401508400048 |
WOS关键词 | PREFERENTIAL HYDRATION ; PHASE-TRANSITION ; PROTEIN ; MECHANISM ; BEHAVIOR ; STRESS ; FUS ; SOLUBILIZATION ; CYTOPLASM ; GRANULES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196092 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Max Planck Inst Mol Cell Biol & Genet, D-01307 Dresden, Germany; 2.Univ Chicago, Dept Chem, 5735 S Ellis Ave, Chicago, IL 60637 USA; 3.Univ Chicago, Grossman Inst Neurosci Quantitat Biol & Human, Chicago, IL 60637 USA |
推荐引用方式 GB/T 7714 | Patel, Avinash,Malinovska, Liliana,Saha, Shambaditya,et al. ATP as a biological hydrotrope[J]. SCIENCE,2017,356(6339):753-756. |
APA | Patel, Avinash.,Malinovska, Liliana.,Saha, Shambaditya.,Wang, Jie.,Alberti, Simon.,...&Hyman, Anthony A..(2017).ATP as a biological hydrotrope.SCIENCE,356(6339),753-756. |
MLA | Patel, Avinash,et al."ATP as a biological hydrotrope".SCIENCE 356.6339(2017):753-756. |
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