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DOI | 10.1126/science.aam7100 |
Rapid binge-like eating and body weight gain driven by zona incerta GABA neuron activation | |
Zhang, Xiaobing; van den Pol, Anthony N. | |
2017-05-26 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 356期号:6340页码:853-858 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | The neuronal substrate for binge eating, which can at times lead to obesity, is not clear. We find that optogenetic stimulation of mouse zona incerta (ZI) gamma-aminobutyric acid (GABA) neurons or their axonal projections to paraventricular thalamus (PVT) excitatory neurons immediately (in 2 to 3 seconds) evoked binge-like eating. Minimal intermittent stimulation led to body weight gain; ZI GABA neuron ablation reduced weight. ZI stimulation generated 35% of normal 24-hour food intake in just 10 minutes. The ZI cells were excited by food deprivation and the gut hunger signal ghrelin. In contrast, stimulation of excitatory axons from the parasubthalamic nucleus to PVT or direct stimulation of PVT glutamate neurons reduced food intake. These data suggest an unexpected robust orexigenic potential for the ZI GABA neurons. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000401957900040 |
WOS关键词 | PARAVENTRICULAR THALAMIC NUCLEUS ; COMORBIDITY-SURVEY-REPLICATION ; PROTEIN-COUPLED RECEPTORS ; DEEP BRAIN-STIMULATION ; PARKINSONS-DISEASE ; PREVALENCE ; DISORDERS ; HYPOTHALAMUS ; PROJECTIONS ; INJECTIONS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196122 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | Yale Univ, Sch Med, Dept Neurosurg, New Haven, CT 06520 USA |
推荐引用方式 GB/T 7714 | Zhang, Xiaobing,van den Pol, Anthony N.. Rapid binge-like eating and body weight gain driven by zona incerta GABA neuron activation[J]. SCIENCE,2017,356(6340):853-858. |
APA | Zhang, Xiaobing,&van den Pol, Anthony N..(2017).Rapid binge-like eating and body weight gain driven by zona incerta GABA neuron activation.SCIENCE,356(6340),853-858. |
MLA | Zhang, Xiaobing,et al."Rapid binge-like eating and body weight gain driven by zona incerta GABA neuron activation".SCIENCE 356.6340(2017):853-858. |
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