Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aal3345 |
A genetic signature of the evolution of loss of flight in the Galapagos cormorant | |
Burga, Alejandro1,2; Wang, Weiguang3,4; Ben-David, Eyal1,2; Wolf, Paul C.5; Ramey, Andrew M.6; Verdugo, Claudio7; Lyons, Karen3,4; Parker, Patricia G.8,9,10; Kruglyak, Leonid1,2 | |
2017-06-02 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 356期号:6341 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Chile |
英文摘要 | We have a limited understanding of the genetic and molecular basis of evolutionary changes in the size and proportion of limbs. We studied wing and pectoral skeleton reduction leading to flightlessness in the Galapagos cormorant (Phalacrocorax harrisi). We sequenced and de novo assembled the genomes of four cormorant species and applied a predictive and comparative genomics approach to find candidate variants that may have contributed to the evolution of flightlessness. These analyses and cross-species experiments in Caenorhabditis elegans and in chondrogenic cell lines implicated variants in genes necessary for transcriptional regulation and function of the primary cilium. Cilia are essential for Hedgehog signaling, and humans affected by skeletal ciliopathies suffer from premature bone growth arrest, mirroring skeletal features associated with loss of flight. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000402552300026 |
WOS关键词 | PLANAR CELL POLARITY ; HOMEODOMAIN PROTEIN ; PRIMARY CILIUM ; CUX1 ; EXPRESSION ; MUTATIONS ; FLIGHTLESSNESS ; DIFFERENTIATION ; CILIOGENESIS ; TRAFFICKING |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196178 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Calif Los Angeles, Dept Biol Chem, Dept Human Genet, Los Angeles, CA 90024 USA; 2.Univ Calif Los Angeles, Howard Hughes Med Inst, Los Angeles, CA 90024 USA; 3.Univ Calif Los Angeles, Dept Mol Cell & Dev Biol, Los Angeles, CA USA; 4.Univ Calif Los Angeles, Dept Orthopaed Surg, Los Angeles, CA USA; 5.USDA, Wildlife Serv, Roseburg, OR USA; 6.US Geol Survey, Alaska Sci Ctr, Anchorage, AK USA; 7.Univ Austral Chile, Fac Ciencias Vet, Inst Patol Anim, Valdivia, Chile; 8.Univ Missouri, Dept Biol, 8001 Nat Bridge Rd, St Louis, MO 63121 USA; 9.Univ Missouri, Whitney Harris World Ecol Ctr, St Louis, MO 63121 USA; 10.St Louis Zoo, WildCare Inst, St Louis, MO USA |
推荐引用方式 GB/T 7714 | Burga, Alejandro,Wang, Weiguang,Ben-David, Eyal,et al. A genetic signature of the evolution of loss of flight in the Galapagos cormorant[J]. SCIENCE,2017,356(6341). |
APA | Burga, Alejandro.,Wang, Weiguang.,Ben-David, Eyal.,Wolf, Paul C..,Ramey, Andrew M..,...&Kruglyak, Leonid.(2017).A genetic signature of the evolution of loss of flight in the Galapagos cormorant.SCIENCE,356(6341). |
MLA | Burga, Alejandro,et al."A genetic signature of the evolution of loss of flight in the Galapagos cormorant".SCIENCE 356.6341(2017). |
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