GSTDTAP  > 地球科学
DOI10.1126/science.aal3345
A genetic signature of the evolution of loss of flight in the Galapagos cormorant
Burga, Alejandro1,2; Wang, Weiguang3,4; Ben-David, Eyal1,2; Wolf, Paul C.5; Ramey, Andrew M.6; Verdugo, Claudio7; Lyons, Karen3,4; Parker, Patricia G.8,9,10; Kruglyak, Leonid1,2
2017-06-02
发表期刊SCIENCE
ISSN0036-8075
EISSN1095-9203
出版年2017
卷号356期号:6341
文章类型Article
语种英语
国家USA; Chile
英文摘要

We have a limited understanding of the genetic and molecular basis of evolutionary changes in the size and proportion of limbs. We studied wing and pectoral skeleton reduction leading to flightlessness in the Galapagos cormorant (Phalacrocorax harrisi). We sequenced and de novo assembled the genomes of four cormorant species and applied a predictive and comparative genomics approach to find candidate variants that may have contributed to the evolution of flightlessness. These analyses and cross-species experiments in Caenorhabditis elegans and in chondrogenic cell lines implicated variants in genes necessary for transcriptional regulation and function of the primary cilium. Cilia are essential for Hedgehog signaling, and humans affected by skeletal ciliopathies suffer from premature bone growth arrest, mirroring skeletal features associated with loss of flight.


领域地球科学 ; 气候变化 ; 资源环境
收录类别SCI-E
WOS记录号WOS:000402552300026
WOS关键词PLANAR CELL POLARITY ; HOMEODOMAIN PROTEIN ; PRIMARY CILIUM ; CUX1 ; EXPRESSION ; MUTATIONS ; FLIGHTLESSNESS ; DIFFERENTIATION ; CILIOGENESIS ; TRAFFICKING
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
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文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/196178
专题地球科学
资源环境科学
气候变化
作者单位1.Univ Calif Los Angeles, Dept Biol Chem, Dept Human Genet, Los Angeles, CA 90024 USA;
2.Univ Calif Los Angeles, Howard Hughes Med Inst, Los Angeles, CA 90024 USA;
3.Univ Calif Los Angeles, Dept Mol Cell & Dev Biol, Los Angeles, CA USA;
4.Univ Calif Los Angeles, Dept Orthopaed Surg, Los Angeles, CA USA;
5.USDA, Wildlife Serv, Roseburg, OR USA;
6.US Geol Survey, Alaska Sci Ctr, Anchorage, AK USA;
7.Univ Austral Chile, Fac Ciencias Vet, Inst Patol Anim, Valdivia, Chile;
8.Univ Missouri, Dept Biol, 8001 Nat Bridge Rd, St Louis, MO 63121 USA;
9.Univ Missouri, Whitney Harris World Ecol Ctr, St Louis, MO 63121 USA;
10.St Louis Zoo, WildCare Inst, St Louis, MO USA
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GB/T 7714
Burga, Alejandro,Wang, Weiguang,Ben-David, Eyal,et al. A genetic signature of the evolution of loss of flight in the Galapagos cormorant[J]. SCIENCE,2017,356(6341).
APA Burga, Alejandro.,Wang, Weiguang.,Ben-David, Eyal.,Wolf, Paul C..,Ramey, Andrew M..,...&Kruglyak, Leonid.(2017).A genetic signature of the evolution of loss of flight in the Galapagos cormorant.SCIENCE,356(6341).
MLA Burga, Alejandro,et al."A genetic signature of the evolution of loss of flight in the Galapagos cormorant".SCIENCE 356.6341(2017).
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