GSTDTAP  > 地球科学
DOI10.1126/science.aan0621
A maternal-effect selfish genetic element in Caenorhabditis elegans
Ben-David, Eyal1; Burga, Alejandro1; Kruglyak, Leonid1
2017-06-09
发表期刊SCIENCE
ISSN0036-8075
EISSN1095-9203
出版年2017
卷号356期号:6342页码:1051-+
文章类型Article
语种英语
国家USA
英文摘要

Selfish genetic elements spread in natural populations and have an important role in genome evolution. We discovered a selfish element causing embryonic lethality in crosses between wild strains of the nematode Caenorhabditis elegans. The element is made up of sup-35, a maternal-effect toxin that kills developing embryos, and pha-1, its zygotically expressed antidote. pha-1 has long been considered essential for pharynx development on the basis of its mutant phenotype, but this phenotype arises from a loss of suppression of sup-35 toxicity. Inactive copies of the sup-35/pha-1 element show high sequence divergence from active copies, and phylogenetic reconstruction suggests that they represent ancestral stages in the evolution of the element. Our results suggest that other essential genes identified by genetic screens may turn out to be components of selfish elements.


领域地球科学 ; 气候变化 ; 资源环境
收录类别SCI-E
WOS记录号WOS:000402871700048
WOS关键词PHARYNGEAL DEVELOPMENT ; DIFFERENTIATION GENE ; GENOME EVOLUTION ; C-ELEGANS ; PHA-1 ; ORGAN ; DROSOPHILA ; DIVERSITY
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
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文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/196207
专题地球科学
资源环境科学
气候变化
作者单位1.Univ Calif Los Angeles, Dept Biol Chem, Dept Human Genet, Los Angeles, CA 90095 USA;
2.Univ Calif Los Angeles, Howard Hughes Med Inst, Los Angeles, CA 90095 USA
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Ben-David, Eyal,Burga, Alejandro,Kruglyak, Leonid. A maternal-effect selfish genetic element in Caenorhabditis elegans[J]. SCIENCE,2017,356(6342):1051-+.
APA Ben-David, Eyal,Burga, Alejandro,&Kruglyak, Leonid.(2017).A maternal-effect selfish genetic element in Caenorhabditis elegans.SCIENCE,356(6342),1051-+.
MLA Ben-David, Eyal,et al."A maternal-effect selfish genetic element in Caenorhabditis elegans".SCIENCE 356.6342(2017):1051-+.
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