Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aan0621 |
A maternal-effect selfish genetic element in Caenorhabditis elegans | |
Ben-David, Eyal1; Burga, Alejandro1; Kruglyak, Leonid1 | |
2017-06-09 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 356期号:6342页码:1051-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Selfish genetic elements spread in natural populations and have an important role in genome evolution. We discovered a selfish element causing embryonic lethality in crosses between wild strains of the nematode Caenorhabditis elegans. The element is made up of sup-35, a maternal-effect toxin that kills developing embryos, and pha-1, its zygotically expressed antidote. pha-1 has long been considered essential for pharynx development on the basis of its mutant phenotype, but this phenotype arises from a loss of suppression of sup-35 toxicity. Inactive copies of the sup-35/pha-1 element show high sequence divergence from active copies, and phylogenetic reconstruction suggests that they represent ancestral stages in the evolution of the element. Our results suggest that other essential genes identified by genetic screens may turn out to be components of selfish elements. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000402871700048 |
WOS关键词 | PHARYNGEAL DEVELOPMENT ; DIFFERENTIATION GENE ; GENOME EVOLUTION ; C-ELEGANS ; PHA-1 ; ORGAN ; DROSOPHILA ; DIVERSITY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196207 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Calif Los Angeles, Dept Biol Chem, Dept Human Genet, Los Angeles, CA 90095 USA; 2.Univ Calif Los Angeles, Howard Hughes Med Inst, Los Angeles, CA 90095 USA |
推荐引用方式 GB/T 7714 | Ben-David, Eyal,Burga, Alejandro,Kruglyak, Leonid. A maternal-effect selfish genetic element in Caenorhabditis elegans[J]. SCIENCE,2017,356(6342):1051-+. |
APA | Ben-David, Eyal,Burga, Alejandro,&Kruglyak, Leonid.(2017).A maternal-effect selfish genetic element in Caenorhabditis elegans.SCIENCE,356(6342),1051-+. |
MLA | Ben-David, Eyal,et al."A maternal-effect selfish genetic element in Caenorhabditis elegans".SCIENCE 356.6342(2017):1051-+. |
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