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DOI | 10.1126/science.aam7928 |
Inflammation and metabolism in tissue repair and regeneration | |
Eming, Sabine A.1,2,3; Wynn, Thomas A.4; Martin, Paul5,6,7,8 | |
2017-06-09 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 356期号:6342页码:1026-1030 |
文章类型 | Review |
语种 | 英语 |
国家 | Germany; USA; England; Wales; Singapore |
英文摘要 | Tissue repair after injury is a complex, metabolically demanding process. Depending on the tissue's regenerative capacity and the quality of the inflammatory response, the outcome is generally imperfect, with some degree of fibrosis, which is defined by aberrant accumulation of collagenous connective tissue. Inflammatory cells multitask at the wound site by facilitating wound debridement and producing chemokines, metabolites, and growth factors. If this well-orchestrated response becomes dysregulated, the wound can become chronic or progressively fibrotic, with both outcomes impairing tissue function, which can ultimately lead to organ failure and death. Here we review the current understanding of the role of inflammation and cell metabolism in tissue-regenerative responses, highlight emerging concepts that may expand therapeutic perspectives, and briefly discuss where important knowledge gaps remain. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000402871700041 |
WOS关键词 | MACROPHAGE POLARIZATION ; SUCCINATE-DEHYDROGENASE ; MEDIATED INFLAMMATION ; PULMONARY-FIBROSIS ; MECHANISMS ; CELLS ; ZEBRAFISH ; DISTINCT ; DISEASE ; HEART |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196209 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Cologne, Dept Dermatol, D-50937 Cologne, Germany; 2.Univ Cologne, Ctr Mol Med Cologne, D-50931 Cologne, Germany; 3.Univ Cologne, Cologne Cluster Excellence Cellular Stress Respon, D-50931 Cologne, Germany; 4.NIAID, Immunopathogenesis Sect, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA; 5.Univ Bristol, Sch Biochem, Bristol, Avon, England; 6.Univ Bristol, Sch Physiol Pharmacol & Neurosci, Bristol, Avon, England; 7.Cardiff Univ, Sch Med, Cardiff, S Glam, Wales; 8.Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore, Singapore |
推荐引用方式 GB/T 7714 | Eming, Sabine A.,Wynn, Thomas A.,Martin, Paul. Inflammation and metabolism in tissue repair and regeneration[J]. SCIENCE,2017,356(6342):1026-1030. |
APA | Eming, Sabine A.,Wynn, Thomas A.,&Martin, Paul.(2017).Inflammation and metabolism in tissue repair and regeneration.SCIENCE,356(6342),1026-1030. |
MLA | Eming, Sabine A.,et al."Inflammation and metabolism in tissue repair and regeneration".SCIENCE 356.6342(2017):1026-1030. |
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