Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aam5894 |
Cardiac regeneration strategies: Staying young at heart | |
Tzahor, Eldad1; Poss, Kenneth D.2,3 | |
2017-06-09 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 356期号:6342页码:1035-1039 |
文章类型 | Review |
语种 | 英语 |
国家 | Israel; USA |
英文摘要 | The human heart is continually operating as a muscular pump, contracting, on average, 80 times per minute to propel 8000 liters of blood through body tissues each day. Whereas damaged skeletal muscle has a profound capacity to regenerate, heart muscle, at least in mammals, has poor regenerative potential. This deficiency is attributable to the lack of resident cardiac stem cells, combined with roadblocks that limit adult cardiomyocytes from entering the cell cycle and completing division. Insights for regeneration have recently emerged from studies of animals with an elevated innate capacity for regeneration, the innovation of stem cell and reprogramming technologies, and a clearer understanding of the cardiomyocyte genetic program and key extrinsic signals. Methods to augment heart regeneration now have potential to counteract the high morbidity and mortality of cardiovascular disease. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000402871700043 |
WOS关键词 | CARDIOMYOCYTE PROLIFERATION ; DEFINED FACTORS ; STEM-CELLS ; FIBROBLASTS ; ZEBRAFISH ; MICE ; DEDIFFERENTIATION ; PREADOLESCENCE ; GENERATION ; RENEWAL |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196212 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Weizmann Inst Sci, Dept Mol Cell Biol, IL-76100 Rehovot, Israel; 2.Duke Univ, Sch Med, Dept Cell Biol, Durham, NC 27710 USA; 3.Duke Univ, Regenerat Next, Durham, NC 27710 USA |
推荐引用方式 GB/T 7714 | Tzahor, Eldad,Poss, Kenneth D.. Cardiac regeneration strategies: Staying young at heart[J]. SCIENCE,2017,356(6342):1035-1039. |
APA | Tzahor, Eldad,&Poss, Kenneth D..(2017).Cardiac regeneration strategies: Staying young at heart.SCIENCE,356(6342),1035-1039. |
MLA | Tzahor, Eldad,et al."Cardiac regeneration strategies: Staying young at heart".SCIENCE 356.6342(2017):1035-1039. |
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