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DOI | 10.1126/science.aal2512 |
PCGF3/5-PRC1 initiates Polycomb recruitment in X chromosome inactivation | |
Almeida, Mafalda1; Pintacuda, Greta1; Masui, Osamu2; Koseki, Yoko2; Gdula, Michal1; Cerase, Andrea1,7; Brown, David3; Mould, Arne4; Innocent, Cassandravictoria5; Nakayama, Manabu6; Schermelleh, Lothar5; Nesterova, Tatyana B.1; Koseki, Haruhiko2; Brockdorff, Neil1 | |
2017-06-09 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 356期号:6342页码:1081-+ |
文章类型 | Article |
语种 | 英语 |
国家 | England; Japan; Italy |
英文摘要 | Recruitment of the Polycomb repressive complexes PRC1 and PRC2 by Xist RNA is an important paradigm for chromatin regulation by long noncoding RNAs. Here, we show that the noncanonical Polycomb group RING finger 3/5 (PCGF3/5)-PRC1 complex initiates recruitment of both PRC1 and PRC2 in response to Xist RNA expression. PCGF3/5-PRC1-mediated ubiquitylation of histone H2A signals recruitment of other noncanonical PRC1 complexes and of PRC2, the latter leading to deposition of histone H3 lysine 27 methylation chromosome-wide. Pcgf3/5 gene knockout results in female-specific embryo lethality and abrogates Xist-mediated gene repression, highlighting a key role for Polycomb in Xist-dependent chromosome silencing. Our findings overturn existing models for Polycomb recruitment by Xist RNA and establish precedence for H2AK119u1 in initiating Polycomb domain formation in a physiological context. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000402871700055 |
WOS关键词 | HISTONE H3 METHYLATION ; XIST RNA ; H2A UBIQUITYLATION ; PRC2 RECRUITMENT ; PROTEINS ; COMPLEXES ; RYBP ; JARID2 |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196218 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Oxford, Dept Biochem, Dev Epigenet, Oxford OX1 3QU, England; 2.RIKEN Ctr Integrat Med Sci, Lab Dev Genet, Tsurumi Ku, 1-7-22 Suehiro, Yokohama, Kanagawa 2300045, Japan; 3.Univ Oxford, Dept Biochem, Chromatin Biol & Transcript, Oxford OX1 3QU, England; 4.Univ Oxford, Sir William Dunn Sch Pathol, Mammalian Dev, South Parks Rd, Oxford OX1 3RE, England; 5.Univ Oxford, Dept Biochem, Micron Adv BioImaging Unit, Oxford OX1 3QU, England; 6.Kazusa DNA Res Inst, 2-6-7 Kazusa Kamatari, Kisarazu, Chiba 2920818, Japan; 7.European Mol Biol Lab Monterotondo, Adriano Buzzati Traverso Campus,Via Ramarini 32, I-00015 Monterotondo, Italy |
推荐引用方式 GB/T 7714 | Almeida, Mafalda,Pintacuda, Greta,Masui, Osamu,et al. PCGF3/5-PRC1 initiates Polycomb recruitment in X chromosome inactivation[J]. SCIENCE,2017,356(6342):1081-+. |
APA | Almeida, Mafalda.,Pintacuda, Greta.,Masui, Osamu.,Koseki, Yoko.,Gdula, Michal.,...&Brockdorff, Neil.(2017).PCGF3/5-PRC1 initiates Polycomb recruitment in X chromosome inactivation.SCIENCE,356(6342),1081-+. |
MLA | Almeida, Mafalda,et al."PCGF3/5-PRC1 initiates Polycomb recruitment in X chromosome inactivation".SCIENCE 356.6342(2017):1081-+. |
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