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DOI | 10.1126/science.aal4713 |
Tubular clathrin/AP-2 lattices pinch collagen fibers to support 3D cell migration | |
Elkhatib, Nadia1; Bresteau, Enzo1; Baschieri, Francesco1; Rioja, Alba Lopez1; van Niel, Guillaume2,4; Vassilopoulos, Stephane3; Montagnac, Guillaume1 | |
2017-06-16 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 356期号:6343 |
文章类型 | Article |
语种 | 英语 |
国家 | France |
英文摘要 | Migrating cells often use focal adhesions in order to move. Focal adhesions are less prominent in cells migrating in three-dimensional (3D) as compared with 2D environments. We looked for alternative adhesion structures supporting cell migration. We analyzed the dynamics of clathrin-coated pits in cells migrating in a 3D environment of collagen fibers. Both topological cues and local engagement of integrins triggered the accumulation of clathrin-coated structures on fibers. Clathrin/adaptor protein 2 (AP-2) lattices pinched collagen fibers by adopting a tube-like morphology and regulated adhesion to fibers in an endocytosis-independent manner. During migration, tubular clathrin/AP-2 lattices stabilized cellular protrusions by providing anchoring points to collagen fibers. Thus, tubular clathrin/AP-2 lattices promote cell adhesion that, in coordination with focal adhesions, supports cell migration in 3D. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000403327400026 |
WOS关键词 | MEDIATED ENDOCYTOSIS ; DEPENDENT ENDOCYTOSIS ; COATED PITS ; ADHESION ; TRAFFICKING ; INTEGRINS ; SUBSTRATE ; DYNAMICS ; EXOCYTOSIS ; TENSION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196285 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Paris Saclay, Gustave Roussy Inst, INSERM, U1170, Villejuif, France; 2.Univ Rech Paris Sci & Lettres, Inst Curie, Ctr Univ, UMR144, Paris, France; 3.Univ Paris 06, INSERM, UMR S974, Inst Myol, Paris, France; 4.INSERM, Ctr Psychiat & Neurosci, U894, Paris, France |
推荐引用方式 GB/T 7714 | Elkhatib, Nadia,Bresteau, Enzo,Baschieri, Francesco,et al. Tubular clathrin/AP-2 lattices pinch collagen fibers to support 3D cell migration[J]. SCIENCE,2017,356(6343). |
APA | Elkhatib, Nadia.,Bresteau, Enzo.,Baschieri, Francesco.,Rioja, Alba Lopez.,van Niel, Guillaume.,...&Montagnac, Guillaume.(2017).Tubular clathrin/AP-2 lattices pinch collagen fibers to support 3D cell migration.SCIENCE,356(6343). |
MLA | Elkhatib, Nadia,et al."Tubular clathrin/AP-2 lattices pinch collagen fibers to support 3D cell migration".SCIENCE 356.6343(2017). |
条目包含的文件 | 条目无相关文件。 |
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