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DOI | 10.1126/science.aal3222 |
An environment-dependent transcriptional network specifies human microglia identity | |
Gosselin, David1; 39;Connor, Carolyn2 | |
2017-06-23 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 356期号:6344 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Netherlands |
英文摘要 | Microglia play essential roles in central nervous system (CNS) homeostasis and influence diverse aspects of neuronal function. However, the transcriptional mechanisms that specify human microglia phenotypes are largely unknown. We examined the transcriptomes and epigenetic landscapes of human microglia isolated from surgically resected brain tissue ex vivo and after transition to an in vitro environment. Transfer to a tissue culture environment resulted in rapid and extensive down-regulation of microglia-specific genes that were induced in primitive mouse macrophages after migration into the fetal brain. Substantial subsets of these genes exhibited altered expression in neurodegenerative and behavioral diseases and were associated with noncoding risk variants. These findings reveal an environment-dependent transcriptional network specifying microglia-specific programs of gene expression and facilitate efforts to understand the roles of microglia in human brain diseases. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000403881700031 |
WOS关键词 | GENE-EXPRESSION ; ALZHEIMERS-DISEASE ; SUPER-ENHANCERS ; CELL IDENTITY ; MACROPHAGE ; INFLAMMATION ; ACTIVATION ; SELECTION ; LINEAGE ; VIABILITY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196319 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Calif San Diego, Dept Cellular & Mol Med, 9500 Gilman Dr, La Jolla, CA 92093 USA; 2.Salk Inst Biol Studies, Genet Lab, 10010 North Torrey Pines Rd, La Jolla, CA 92037 USA; 3.Univ Calif San Diego, Dept Pediat, 9500 Gilman Dr, La Jolla, CA 92093 USA; 4.Univ Groningen, Univ Med Ctr Groningen, Dept Neurosci, Sect Med Physiol, Groningen, Netherlands; 5.Univ Calif San Diego, Rady Childrens Hosp, Dept Neurosurg, San Diego, CA 92123 USA; 6.Biogen, Neuroimmunol, 225 Binney St, Cambridge, MA 02142 USA; 7.Univ Calif San Diego, Dept Med, 9500 Gilman Dr, La Jolla, CA 92093 USA |
推荐引用方式 GB/T 7714 | Gosselin, David,39;Connor, Carolyn. An environment-dependent transcriptional network specifies human microglia identity[J]. SCIENCE,2017,356(6344). |
APA | Gosselin, David,&39;Connor, Carolyn.(2017).An environment-dependent transcriptional network specifies human microglia identity.SCIENCE,356(6344). |
MLA | Gosselin, David,et al."An environment-dependent transcriptional network specifies human microglia identity".SCIENCE 356.6344(2017). |
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