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DOI | 10.1126/science.aam8334 |
Improving vaccine trials in infectious disease emergencies | |
Lipsitch, Marc1,2; Eyal, Nir3 | |
2017-07-14 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 357期号:6347页码:153-+ |
文章类型 | Review |
语种 | 英语 |
国家 | USA |
英文摘要 | Unprecedented global effort is under way to facilitate the testing of countermeasures in infectious disease emergencies. Better understanding of the various options for trial design is needed in advance of outbreaks, as is preliminary global agreement on the most suitable designs for the various scenarios. What would enhance the speed, validity, and ethics of clinical studies of such countermeasures? Focusing on studies of vaccine efficacy and effectiveness in emergencies, we highlight three needs: for formal randomized trialseven in most emergencies; for individually randomized trials-even in many emergencies; and for six areas of innovation in trial methodology. These needs should inform current updates of protocols and roadmaps. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000405391700035 |
WOS关键词 | EBOLA-VIRUS DISEASE ; RING VACCINATION ; SIERRA-LEONE ; DESIGN ; EFFICACY ; ZIKA ; GUINEA ; PREVENTION ; EPIDEMIC ; RISK |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196457 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Ctr Communicable Dis Dynam, Boston, MA 02115 USA; 2.Harvard TH Chan Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA; 3.Harvard TH Chan Sch Publ Hlth, Dept Global Hlth & Populat, Boston, MA USA |
推荐引用方式 GB/T 7714 | Lipsitch, Marc,Eyal, Nir. Improving vaccine trials in infectious disease emergencies[J]. SCIENCE,2017,357(6347):153-+. |
APA | Lipsitch, Marc,&Eyal, Nir.(2017).Improving vaccine trials in infectious disease emergencies.SCIENCE,357(6347),153-+. |
MLA | Lipsitch, Marc,et al."Improving vaccine trials in infectious disease emergencies".SCIENCE 357.6347(2017):153-+. |
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