Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aal1962 |
Mouse models of acute and chronic hepacivirus infection | |
Billerbeck, Eva1; Wolfisberg, Raphael2,3,4; Fahnoe, Ulrik2,3,4; Xiao, Jing W.1; Quirk, Corrine1; Luna, Joseph M.1; Cullen, John M.5; Hartlage, Alex S.6,7; Chiriboga, Luis8; Ghoshal, Kalpana9; Lipkin, W. Ian10; Bukh, Jens2,3,4; Scheel, Troels K. H.1,2,3,4; Kapoor, Amit6,7; Rice, Charles M.1 | |
2017-07-14 | |
发表期刊 | SCIENCE
![]() |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 357期号:6347页码:204-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Denmark |
英文摘要 | An estimated 71 million people worldwide are infected with hepatitis C virus (HCV). The lack of small-animal models has impeded studies of antiviral immune mechanisms. Here we show that an HCV-related hepacivirus discovered in Norway rats can establish high-titer hepatotropic infections in laboratory mice with immunological features resembling those seen in human viral hepatitis. Whereas immune-compromised mice developed persistent infection, immune-competent mice cleared the virus within 3 to 5 weeks. Acute clearance was T cell dependent and associated with liver injury. Transient depletion of CD4(+) T cells before infection resulted in chronic infection, characterized by high levels of intrahepatic regulatory T cells and expression of inhibitory molecules on intrahepatic CD8(+) T cells. Natural killer cells controlled early infection but were not essential for viral clearance. This model may provide mechanistic insights into hepatic antiviral immunity, a prerequisite for the development of HCV vaccines. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000405391700047 |
WOS关键词 | HEPATITIS-C VIRUS ; CHRONIC VIRAL-INFECTION ; T-CELL EXHAUSTION ; PERSISTENT INFECTION ; NK CELLS ; MEMORY ; LIVER ; VACCINE |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196466 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Rockefeller Univ, Lab Virol & Infect Dis, 1230 York Ave, New York, NY 10021 USA; 2.Hvidovre Univ Hosp, Dept Infect Dis, Copenhagen Hepatitis Program CO HEP C, Copenhagen, Denmark; 3.Hvidovre Univ Hosp, Clin Res Ctr, Copenhagen, Denmark; 4.Univ Copenhagen, Fac Hlth & Med Sci, Dept Immunol & Microbiol, Copenhagen, Denmark; 5.North Carolina State Univ, Coll Vet Med, Raleigh, NC USA; 6.Nationwide Childrens Hosp, Res Inst, Ctr Vaccines & Immun, Columbus, OH USA; 7.Ohio State Univ, Dept Pediat, Columbus, OH 43210 USA; 8.NYU, Dept Pathol, Med Ctr, 550 1St Ave, New York, NY 10016 USA; 9.Ohio State Univ, Dept Pathol, Comprehens Canc Ctr, Columbus, OH 43210 USA; 10.Columbia Univ, Mailman Sch Publ Hlth, Ctr Infect & Immun, New York, NY USA |
推荐引用方式 GB/T 7714 | Billerbeck, Eva,Wolfisberg, Raphael,Fahnoe, Ulrik,et al. Mouse models of acute and chronic hepacivirus infection[J]. SCIENCE,2017,357(6347):204-+. |
APA | Billerbeck, Eva.,Wolfisberg, Raphael.,Fahnoe, Ulrik.,Xiao, Jing W..,Quirk, Corrine.,...&Rice, Charles M..(2017).Mouse models of acute and chronic hepacivirus infection.SCIENCE,357(6347),204-+. |
MLA | Billerbeck, Eva,et al."Mouse models of acute and chronic hepacivirus infection".SCIENCE 357.6347(2017):204-+. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论