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DOI | 10.1126/science.aaf9794 |
Kynurenines: Tryptophan's metabolites in exercise, inflammation, and mental health | |
Cervenka, Igor; Agudelo, Leandro Z.; Ruas, Jorge L. | |
2017-07-28 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 357期号:6349 |
文章类型 | Review |
语种 | 英语 |
国家 | Sweden |
英文摘要 | Kynurenine metabolites are generated by tryptophan catabolism and regulate biological processes that include host-microbiome signaling, immune cell response, and neuronal excitability. Enzymes of the kynurenine pathway are expressed in different tissues and cell types throughout the body and are regulated by cues, including nutritional and inflammatory signals. As a consequence of this systemic metabolic integration, peripheral inflammation can contribute to accumulation of kynurenine in the brain, which has been associated with depression and schizophrenia. Conversely, kynurenine accumulation can be suppressed by activating kynurenine clearance in exercised skeletal muscle. The effect of exercise training on depression through modulation of the kynurenine pathway highlights an important mechanism of interorgan cross-talk mediated by these metabolites. Here, we discuss peripheral mechanisms of tryptophan-kynurenine metabolism and their effects on inflammatory, metabolic, oncologic, and psychiatric disorders. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E ; SSCI |
WOS记录号 | WOS:000406362300034 |
WOS关键词 | ARYL-HYDROCARBON RECEPTOR ; AMINO-ACID TRANSPORTER ; INDOLEAMINE 2,3-DIOXYGENASE ACTIVITY ; TYPE-2 DIABETES-MELLITUS ; IRRITABLE-BOWEL-SYNDROME ; BLOOD-BRAIN-BARRIER ; REGULATORY T-CELLS ; DENDRITIC CELLS ; QUINOLINIC ACID ; ACUTE-PANCREATITIS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196561 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | Karolinska Inst, Dept Physiol & Pharmacol Mol & Cellular Exercise, SE-17177 Stockholm, Sweden |
推荐引用方式 GB/T 7714 | Cervenka, Igor,Agudelo, Leandro Z.,Ruas, Jorge L.. Kynurenines: Tryptophan's metabolites in exercise, inflammation, and mental health[J]. SCIENCE,2017,357(6349). |
APA | Cervenka, Igor,Agudelo, Leandro Z.,&Ruas, Jorge L..(2017).Kynurenines: Tryptophan's metabolites in exercise, inflammation, and mental health.SCIENCE,357(6349). |
MLA | Cervenka, Igor,et al."Kynurenines: Tryptophan's metabolites in exercise, inflammation, and mental health".SCIENCE 357.6349(2017). |
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