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DOI | 10.1126/science.aan0178 |
UBE2O is a quality control factor for orphans of multiprotein complexes | |
Yanagitani, Kota1,2; Juszkiewicz, Szymon1; Hegde, Ramanujan S.1 | |
2017-08-04 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 357期号:6350页码:472-+ |
文章类型 | Article |
语种 | 英语 |
国家 | England; Japan |
英文摘要 | Many nascent proteins are assembled into multiprotein complexes of defined stoichiometry. Imbalances in the synthesis of individual subunits result in orphans. How orphans are selectively eliminated to maintain protein homeostasis is poorly understood. Here, we found that the conserved ubiquitin-conjugating enzyme UBE2O directly recognized juxtaposed basic and hydrophobic patches on unassembled proteins to mediate ubiquitination without a separate ubiquitin ligase. In reticulocytes, where UBE2O is highly up-regulated, unassembled a-globin molecules that failed to assemble with beta-globin were selectively ubiquitinated by UBE2O. In nonreticulocytes, ribosomal proteins that did not engage nuclear import factors were targets for UBE2O. Thus, UBE2O is a self-contained quality control factor that comprises substrate recognition and ubiquitin transfer activities within a single protein to efficiently target orphans of multiprotein complexes for degradation. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000406840100030 |
WOS关键词 | SACCHAROMYCES-CEREVISIAE ; MISLOCALIZED PROTEINS ; MEMBRANE-PROTEINS ; ALPHA-HEMOGLOBIN ; DEGRADATION ; THERAPY ; CELLS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196601 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.MRC, Lab Mol Biol, Francis Crick Ave,Cambridge Biomed Campus, Cambridge CB2 0QH, England; 2.Thomas N Sato BioMEC X Labs, Adv Telecommun Res Inst Int ATR, Hikaridai 2-2-2, Kyoto 6190288, Japan |
推荐引用方式 GB/T 7714 | Yanagitani, Kota,Juszkiewicz, Szymon,Hegde, Ramanujan S.. UBE2O is a quality control factor for orphans of multiprotein complexes[J]. SCIENCE,2017,357(6350):472-+. |
APA | Yanagitani, Kota,Juszkiewicz, Szymon,&Hegde, Ramanujan S..(2017).UBE2O is a quality control factor for orphans of multiprotein complexes.SCIENCE,357(6350),472-+. |
MLA | Yanagitani, Kota,et al."UBE2O is a quality control factor for orphans of multiprotein complexes".SCIENCE 357.6350(2017):472-+. |
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