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DOI | 10.1126/science.aan3458 |
Pavlovian conditioning-induced hallucinations result from overweighting of perceptual priors | |
Powers, A. R.1; Mathys, C.2,3,4,5; Corlett, P. R.1 | |
2017-08-11 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 357期号:6351页码:596-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; Italy; England; Switzerland |
英文摘要 | Some people hear voices that others do not, but only some of those people seek treatment. Using a Pavlovian learning task, we induced conditioned hallucinations in four groups of people who differed orthogonally in their voice-hearing and treatment-seeking statuses. People who hear voices were significantly more susceptible to the effect. Using functional neuroimaging and computational modeling of perception, we identified processes that differentiated voice-hearers from non-voice-hearers and treatment-seekers from non-treatment-seekers and characterized a brain circuit that mediated the conditioned hallucinations. These data demonstrate the profound and sometimes pathological impact of top-down cognitive processes on perception and may represent an objective means to discern people with a need for treatment from those without. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E ; SSCI |
WOS记录号 | WOS:000407324800042 |
WOS关键词 | SCHIZOPHRENIA ; PSYCHOSIS ; UNCERTAINTY ; PREDICTION ; CONTINUUM ; CORTEX |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196638 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06510 USA; 2.Int Sch Adv Studies SISSA, Trieste, Italy; 3.Max Planck Univ Coll London UCL, Ctr Computat Psychiat & Ageing Res, London, England; 4.Univ Zurich, TNU, Inst Biomed Engn, Zurich, Switzerland; 5.Swiss Fed Inst Technol, Zurich, Switzerland |
推荐引用方式 GB/T 7714 | Powers, A. R.,Mathys, C.,Corlett, P. R.. Pavlovian conditioning-induced hallucinations result from overweighting of perceptual priors[J]. SCIENCE,2017,357(6351):596-+. |
APA | Powers, A. R.,Mathys, C.,&Corlett, P. R..(2017).Pavlovian conditioning-induced hallucinations result from overweighting of perceptual priors.SCIENCE,357(6351),596-+. |
MLA | Powers, A. R.,et al."Pavlovian conditioning-induced hallucinations result from overweighting of perceptual priors".SCIENCE 357.6351(2017):596-+. |
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