Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aaj1849 |
Structure of histone-based chromatin in Archaea | |
Mattiroli, Francesca1; Bhattacharyya, Sudipta2,6; Dyer, Pamela N.1; White, Alison E.1; Sandman, Kathleen3; Burkhart, Brett W.2; Byrne, Kyle R.2; Lee, Thomas1; Ahn, Natalie G.1; Santangelo, Thomas J.2,4; Reeve, John N.3; Luger, Karolin1,4,5 | |
2017-08-11 | |
发表期刊 | SCIENCE
![]() |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 357期号:6351页码:609-611 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Small basic proteins present in most Archaea share a common ancestor with the eukaryotic core histones. We report the crystal structure of an archaeal histone-DNA complex. DNA wraps around an extended polymer, formed by archaeal histone homodimers, in a quasi-continuous superhelix with the same geometry as DNA in the eukaryotic nucleosome. Substitutions of a conserved glycine at the interface of adjacent protein layers destabilize archaeal chromatin, reduce growth rate, and impair transcription regulation, confirming the biological importance of the polymeric structure. Our data establish that the histone-based mechanism of DNA compaction predates the nucleosome, illuminating the origin of the nucleosome. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000407324800045 |
WOS关键词 | THERMOCOCCUS-KODAKARENSIS ; CRYSTAL-STRUCTURE ; NUCLEOSOME ; ORIGIN ; DNA ; FOLD |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196650 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Colorado Boulder, Dept Chem & Biochem, Boulder, CO 80309 USA; 2.Colorado State Univ, Dept Biochem & Mol Biol, Ft Collins, CO 80523 USA; 3.Ohio State Univ, Dept Microbiol, 484 W 12th Ave, Columbus, OH 43210 USA; 4.Colorado State Univ, Inst Genome Architecture & Funct, Ft Collins, CO 80523 USA; 5.Univ Colorado Boulder, Howard Hughes Med Inst, Boulder, CO 80309 USA; 6.Univ Texas Austin, Dept Mol Biosci, Austin, TX 78712 USA |
推荐引用方式 GB/T 7714 | Mattiroli, Francesca,Bhattacharyya, Sudipta,Dyer, Pamela N.,et al. Structure of histone-based chromatin in Archaea[J]. SCIENCE,2017,357(6351):609-611. |
APA | Mattiroli, Francesca.,Bhattacharyya, Sudipta.,Dyer, Pamela N..,White, Alison E..,Sandman, Kathleen.,...&Luger, Karolin.(2017).Structure of histone-based chromatin in Archaea.SCIENCE,357(6351),609-611. |
MLA | Mattiroli, Francesca,et al."Structure of histone-based chromatin in Archaea".SCIENCE 357.6351(2017):609-611. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论