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DOI | 10.1126/science.aan8552 |
Structure of the complete elongation complex of RNA polymerase II with basal factors | |
Ehara, Haruhiko1; Yokoyama, Takeshi1; Shigematsu, Hideki1; Yokoyama, Shigeyuki2; Shirouzu, Mikako1; Sekine, Shun-ichi1 | |
2017-09-01 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 357期号:6354页码:921-924 |
文章类型 | Article |
语种 | 英语 |
国家 | Japan |
英文摘要 | In the early stage of transcription, eukaryotic RNA polymerase II (Pol II) exchanges initiation factors with elongation factors to form an elongation complex for processive transcription. Here we report the structure of the Pol II elongation complex bound with the basal elongation factors Spt4/5, Elf1, and TFIIS. Spt4/5 (the Spt4/Spt5 complex) and Elf1 modify a wide area of the Pol II surface. Elf1 bridges the Pol II central cleft, completing a "DNA entry tunnel" for downstream DNA. Spt4 and the Spt5 NGN and KOW1 domains encircle the upstream DNA, constituting a "DNA exit tunnel." The Spt5 KOW4 and KOW5 domains augment the "RNA exit tunnel," directing the exiting nascent RNA. Thus, the elongation complex establishes a completely different transcription and regulation platform from that of the initiation complexes. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000408734900043 |
WOS关键词 | SENSITIVITY-INDUCING FACTOR ; TRANSCRIPTION ELONGATION ; FACTOR SPT5 ; DOMAINS ; CLAMP ; DSIF ; PHOSPHORYLATION ; IDENTIFICATION ; PROCESSIVITY ; INITIATION |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196763 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.RIKEN, Ctr Life Sci Technol, Tsuzuki Ku, 1-7-22 Suehiro Cho, Yokohama, Kanagawa 2300045, Japan; 2.RIKEN, Struct Biol Lab, Tsuzuki Ku, 1-7-22 Suehiro Cho, Yokohama, Kanagawa 2300045, Japan |
推荐引用方式 GB/T 7714 | Ehara, Haruhiko,Yokoyama, Takeshi,Shigematsu, Hideki,et al. Structure of the complete elongation complex of RNA polymerase II with basal factors[J]. SCIENCE,2017,357(6354):921-924. |
APA | Ehara, Haruhiko,Yokoyama, Takeshi,Shigematsu, Hideki,Yokoyama, Shigeyuki,Shirouzu, Mikako,&Sekine, Shun-ichi.(2017).Structure of the complete elongation complex of RNA polymerase II with basal factors.SCIENCE,357(6354),921-924. |
MLA | Ehara, Haruhiko,et al."Structure of the complete elongation complex of RNA polymerase II with basal factors".SCIENCE 357.6354(2017):921-924. |
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