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DOI | 10.1126/science.aam9335 |
A microtubule-organizing center directing intracellular transport in the early mouse embryo | |
Zenker, J.1; White, M. D.1; Templin, R. M.2,3; Parton, R. G.2,3; Thorn-Seshold, O.4; Bissiere, S.1; Plachta, N.1,5 | |
2017-09-01 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 357期号:6354页码:925-+ |
文章类型 | Article |
语种 | 英语 |
国家 | Singapore; Australia; Germany |
英文摘要 | The centrosome is the primary microtubule-organizing center (MTOC) of most animal cells; however, this organelle is absent during early mammalian development. Therefore, the mechanism by which the mammalian embryo organizes its microtubules (MTs) is unclear. We visualize MT bridges connecting pairs of cells and show that the cytokinetic bridge does not undergo stereotypical abscission after cell division. Instead, it serves as scaffold for the accumulation of the MT minus-end-stabilizing protein CAMSAP3 throughout interphase, thereby transforming this structure into a noncentrosomal MTOC. Transport of the cell adhesion molecule E-cadherin to the membrane is coordinated by this MTOC and is required to form the pluripotent inner mass. Our study reveals a noncentrosomal form of MT organization that directs intracellular transport and is essential for mammalian development. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000408734900044 |
WOS关键词 | ADHERENS JUNCTIONS ; GOLGI NETWORK ; E-CADHERIN ; CENTROSOME ; NUCLEATION ; ENDOSOMES ; BIOGENESIS ; MECHANISMS ; PROTEINS ; POLARITY |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196771 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.ASTAR, Inst Mol & Cell Biol, Singapore, Singapore; 2.Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia; 3.Univ Queensland, Ctr Microscopy & Microanal, Brisbane, Qld, Australia; 4.Ludwig Maximilians Univ Munchen, Dept Pharm, Ctr Drug Res, Munich, Germany; 5.Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biochem, Singapore, Singapore |
推荐引用方式 GB/T 7714 | Zenker, J.,White, M. D.,Templin, R. M.,et al. A microtubule-organizing center directing intracellular transport in the early mouse embryo[J]. SCIENCE,2017,357(6354):925-+. |
APA | Zenker, J..,White, M. D..,Templin, R. M..,Parton, R. G..,Thorn-Seshold, O..,...&Plachta, N..(2017).A microtubule-organizing center directing intracellular transport in the early mouse embryo.SCIENCE,357(6354),925-+. |
MLA | Zenker, J.,et al."A microtubule-organizing center directing intracellular transport in the early mouse embryo".SCIENCE 357.6354(2017):925-+. |
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