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DOI | 10.1126/science.aan3846 |
Behavioral time scale synaptic plasticity underlies CA1 place fields | |
Bittner, Katie C.1; Milstein, Aaron D.1,2; Grienberger, Christine1; Romani, Sandro1; Magee, Jeffrey C.1 | |
2017-09-08 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 357期号:6355页码:1033-1036 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Learning is primarily mediated by activity-dependent modifications of synaptic strength within neuronal circuits. We discovered that place fields in hippocampal area CA1 are produced by a synaptic potentiation notably different from Hebbian plasticity. Place fields could be produced in vivo in a single trial by potentiation of input that arrived seconds before and after complex spiking. The potentiated synaptic input was not initially coincident with action potentials or depolarization. This rule, named behavioral timescale synaptic plasticity, abruptly modifies inputs that were neither causal nor close in time to postsynaptic activation. In slices, five pairings of subthreshold presynaptic activity and calcium (Ca2+) plateau potentials produced a large potentiation with an asymmetric seconds-long time course. This plasticity efficiently stores entire behavioral sequences within synaptic weights to produce predictive place cell activity. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000409455700043 |
WOS关键词 | TIMING-DEPENDENT PLASTICITY ; LONG-TERM POTENTIATION ; HIPPOCAMPUS ; NAVIGATION ; NEURONS ; MEMORY ; CELLS ; ACTIVATION ; SYSTEMS ; BRAIN |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196821 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Howard Hughes Med Inst, Janelia Res Campus, Ashburn, VA 20147 USA; 2.Stanford Univ, Sch Med, Dept Neurosurg, Stanford, CA 94305 USA |
推荐引用方式 GB/T 7714 | Bittner, Katie C.,Milstein, Aaron D.,Grienberger, Christine,et al. Behavioral time scale synaptic plasticity underlies CA1 place fields[J]. SCIENCE,2017,357(6355):1033-1036. |
APA | Bittner, Katie C.,Milstein, Aaron D.,Grienberger, Christine,Romani, Sandro,&Magee, Jeffrey C..(2017).Behavioral time scale synaptic plasticity underlies CA1 place fields.SCIENCE,357(6355),1033-1036. |
MLA | Bittner, Katie C.,et al."Behavioral time scale synaptic plasticity underlies CA1 place fields".SCIENCE 357.6355(2017):1033-1036. |
条目包含的文件 | 条目无相关文件。 |
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