Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1126/science.aan6558 |
A cargo-sorting DNA robot | |
Thubagere, Anupama J.1; Li, Wei1; Johnson, Robert F.1; Chen, Zibo1; Doroudi, Shayan2; Lee, Yae Lim3; Izatt, Gregory2,4; Wittman, Sarah2; Srinivas, Niranjan4; Woods, Damien2,5; Winfree, Erik1,2,4; Qian, Lulu1,2 | |
2017-09-15 | |
发表期刊 | SCIENCE |
ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 357期号:6356 |
文章类型 | Article |
语种 | 英语 |
国家 | USA; France |
英文摘要 | Two critical challenges in the design and synthesis of molecular robots are modularity and algorithm simplicity. We demonstrate three modular building blocks for a DNA robot that performs cargo sorting at themolecular level. A simple algorithm encoding recognition between cargos and their destinations allows for a simple robot design: a single-stranded DNA with one leg and two foot domains for walking, and one arm and one hand domain for picking up and dropping off cargos. The robot explores a two-dimensional testing ground on the surface of DNA origami, picks up multiple cargos of two types that are initially at unordered locations, and delivers them to specified destinations until all molecules are sorted into two distinct piles. The robot is designed to perform a random walk without any energy supply. Exploiting this feature, a single robot can repeatedly sort multiple cargos. Localization on DNA origami allows for distinct cargo-sorting tasks to take place simultaneously in one test tube or for multiple robots to collectively perform the same task. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000410639800034 |
WOS关键词 | SELF-ORGANIZATION ; MOTOR PROTEINS ; WALKER ; TRANSPORT ; BINDING |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196873 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.CALTECH, Bioengn, Pasadena, CA 91125 USA; 2.CALTECH, Comp Sci, Pasadena, CA 91125 USA; 3.CALTECH, Elect Engn, Pasadena, CA 91125 USA; 4.CALTECH, Computat & Neural Syst, Pasadena, CA 91125 USA; 5.INRIA, Paris, France |
推荐引用方式 GB/T 7714 | Thubagere, Anupama J.,Li, Wei,Johnson, Robert F.,et al. A cargo-sorting DNA robot[J]. SCIENCE,2017,357(6356). |
APA | Thubagere, Anupama J..,Li, Wei.,Johnson, Robert F..,Chen, Zibo.,Doroudi, Shayan.,...&Qian, Lulu.(2017).A cargo-sorting DNA robot.SCIENCE,357(6356). |
MLA | Thubagere, Anupama J.,et al."A cargo-sorting DNA robot".SCIENCE 357.6356(2017). |
条目包含的文件 | 条目无相关文件。 |
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