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DOI | 10.1126/science.aan5544 |
The form and function of channelrhodopsin | |
Deisseroth, Karl1,2,3; Hegemann, Peter4,5 | |
2017-09-15 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 357期号:6356 |
文章类型 | Review |
语种 | 英语 |
国家 | USA; Germany |
英文摘要 | Channelrhodopsins are light-gated ion channels that, via regulation of flagellar function, enable single-celled motile algae to seek ambient light conditions suitable for photosynthesis and survival. These plant behavioral responses were initially investigated more than 150 years ago. Recently, major principles of function for light-gated ion channels have been elucidated by creating channelrhodopsins with kinetics that are accelerated or slowed over orders of magnitude, by discovering and designing channelrhodopsins with altered spectral properties, by solving the high-resolution channelrhodopsin crystal structure, and by structural model-guided redesign of channelrhodopsins for altered ion selectivity. Each of these discoveries not only revealed basic principles governing the operation of light-gated ion channels, but also enabled the creation of new proteins for illuminating, via optogenetics, the fundamentals of brain function. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000410639800033 |
WOS关键词 | CHLORIDE-CONDUCTING CHANNELRHODOPSIN ; OPTOGENETIC CONTROL ; CHLAMYDOMONAS-REINHARDTII ; ION SELECTIVITY ; GREEN-ALGAE ; RETINAL CHROMOPHORE ; REMOTE-CONTROL ; ALL-TRANS ; IN-VIVO ; LIGHT |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/196876 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA; 2.Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA; 3.Stanford Univ, Howard Hughes Med Inst, Stanford, CA 94305 USA; 4.Humboldt Univ, Inst Biol, D-10115 Berlin, Germany; 5.Humboldt Univ, Expt Biophys, D-10115 Berlin, Germany |
推荐引用方式 GB/T 7714 | Deisseroth, Karl,Hegemann, Peter. The form and function of channelrhodopsin[J]. SCIENCE,2017,357(6356). |
APA | Deisseroth, Karl,&Hegemann, Peter.(2017).The form and function of channelrhodopsin.SCIENCE,357(6356). |
MLA | Deisseroth, Karl,et al."The form and function of channelrhodopsin".SCIENCE 357.6356(2017). |
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