GSTDTAP  > 地球科学
DOI10.1126/science.aan3925
DNA sequence-directed shape change of photopatterned hydrogels via high-degree swelling
Cangialosi, Angelo1; Yoon, ChangKyu2; Liu, Jiayu3; Huang, Qi1; Guo, Jingkai3; Nguyen, Thao D.2,3; Gracias, David H.1,2; Schulman, Rebecca1,4
2017-09-15
发表期刊SCIENCE
ISSN0036-8075
EISSN1095-9203
出版年2017
卷号357期号:6356页码:1126-1129
文章类型Article
语种英语
国家USA
英文摘要

Shape-changing hydrogels that can bend, twist, or actuate in response to external stimuli are critical to soft robots, programmable matter, and smart medicine. Shape change in hydrogels has been induced by global cues, including temperature, light, or pH. Here we demonstrate that specific DNA molecules can induce 100-fold volumetric hydrogel expansion by successive extension of cross-links. We photopattern up to centimeter-sized gels containing multiple domains that undergo different shape changes in response to different DNA sequences. Experiments and simulations suggest a simple design rule for controlled shape change. Because DNA molecules can be coupled to molecular sensors, amplifiers, and logic circuits, this strategy introduces the possibility of building soft devices that respond to diverse biochemical inputs and autonomously implement chemical control programs.


领域地球科学 ; 气候变化 ; 资源环境
收录类别SCI-E
WOS记录号WOS:000410639800038
WOS关键词NANOPARTICLE SUPERLATTICES ; HYBRIDIZATION ; RESPONSES ; NETWORKS ; HYBRIDS
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
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文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/196879
专题地球科学
资源环境科学
气候变化
作者单位1.Johns Hopkins Univ, Dept Chem & Biomol Engn, Baltimore, MD 21218 USA;
2.Johns Hopkins Univ, Dept Mat Sci & Engn, Baltimore, MD 21218 USA;
3.Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA;
4.Johns Hopkins Univ, Dept Comp Sci, Baltimore, MD 21218 USA
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Cangialosi, Angelo,Yoon, ChangKyu,Liu, Jiayu,et al. DNA sequence-directed shape change of photopatterned hydrogels via high-degree swelling[J]. SCIENCE,2017,357(6356):1126-1129.
APA Cangialosi, Angelo.,Yoon, ChangKyu.,Liu, Jiayu.,Huang, Qi.,Guo, Jingkai.,...&Schulman, Rebecca.(2017).DNA sequence-directed shape change of photopatterned hydrogels via high-degree swelling.SCIENCE,357(6356),1126-1129.
MLA Cangialosi, Angelo,et al."DNA sequence-directed shape change of photopatterned hydrogels via high-degree swelling".SCIENCE 357.6356(2017):1126-1129.
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