Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques

doi:10.1126/science.aan8630

GSTDTAP > 地球科学

DOI	10.1126/science.aan8630
	Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques
	Xu, Ling 1; 39;Dell, Sijy 2
	2017-10-06
发表期刊	SCIENCE
ISSN	0036-8075
EISSN	1095-9203
出版年	2017
卷号	358 期号:6359 页码:85-89
文章类型	Article
语种	英语
国家	USA
英文摘要	The development of an effective AIDS vaccine has been challenging because of viral genetic diversity and the difficulty of generating broadly neutralizing antibodies (bnAbs). We engineered trispecific antibodies (Abs) that allow a single molecule to interact with three independent HIV-1 envelope determinants: the CD4 binding site, the membrane-proximal external region (MPER), and the V1V2 glycan site. Trispecific Abs exhibited higher potency and breadth than any previously described single bnAb, showed pharmacokinetics similar to those of human bnAbs, and conferred complete immunity against a mixture of simian-human immunodeficiency viruses (SHIVs) in nonhuman primates, in contrast to single bnAbs. Trispecific Abs thus constitute a platform to engage multiple therapeutic targets through a single protein, and they may be applicable for treatment of diverse diseases, including infections, cancer, and autoimmunity.
领域	地球科学 ; 气候变化 ; 资源环境
收录类别	SCI-E
WOS记录号	WOS:000412359600057
WOS关键词	BISPECIFIC ANTIBODIES ; MATURATION ; IDENTIFICATION ; THERAPY ; BREADTH
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
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引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/197019
专题	地球科学资源环境科学气候变化
作者单位	1.Sanofi, 640 Mem Dr, Cambridge, MA 02139 USA; 2.NIAID, Vaccine Res Ctr, 9000 Rockville Pike, Bethesda, MD 20892 USA; 3.Harvard Med Sch, Ctr Virol & Vaccine Res, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA; 4.Ragon Inst MGH MIT & Harvard, Cambridge, MA 02139 USA; 5.Scripps Res Inst, Dept Immunol & Microbiol, Int AIDS Vaccine Initiat IAVI Neutralizing Antibo, Ctr HIV AIDS Vaccine Immunol & Immunogen Discover, La Jolla, CA 92037 USA; 6.NIAID, 9000 Rockville Pike, Bethesda, MD 20892 USA
推荐引用方式 GB/T 7714	Xu, Ling,39;Dell, Sijy. Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques[J]. SCIENCE,2017,358(6359):85-89.
APA	Xu, Ling,&39;Dell, Sijy.(2017).Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques.SCIENCE,358(6359),85-89.
MLA	Xu, Ling,et al."Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques".SCIENCE 358.6359(2017):85-89.