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DOI | 10.1126/science.aam9690 |
Visualizing the function and fate of neutrophils in sterile injury and repair | |
Wang, Jing1,2,3; Hossain, Mokarram1,3; Thanabalasuriar, Ajitha1,3; Gunzer, Matthias4; Meininger, Cynthia5; Kubes, Paul1,3,6 | |
2017-10-06 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 358期号:6359页码:111-115 |
文章类型 | Article |
语种 | 英语 |
国家 | Canada; Japan; Germany; USA |
英文摘要 | Neutrophils have been implicated as harmful cells in a variety of inappropriate inflammatory conditions where they injure the host, leading to the death of the neutrophils and their subsequent phagocytosis by monocytes and macrophages. Here we show that in a fully repairing sterile thermal hepatic injury, neutrophils also penetrate the injury site and perform the critical tasks of dismantling injured vessels and creating channels for new vascular regrowth. Upon completion of these tasks, they neither die at the injury site nor are phagocytosed. Instead, many of these neutrophils reenter the vasculature and have a preprogrammed journey that entails a sojourn in the lungs to up-regulate CXCR4 (C-X-C motif chemokine receptor 4) before entering the bone marrow, where they undergo apoptosis. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000412359600064 |
WOS关键词 | APOPTOTIC CELLS ; BONE-MARROW ; IN-VIVO ; INFLAMMATION ; MIGRATION ; PHAGOCYTOSIS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197026 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Calgary, Dept Physiol & Pharmacol, Calgary, AB T2N 4N1, Canada; 2.Tokushima Univ, Div Inflammat Biol, Tokushima 7708503, Japan; 3.Univ Calgary, Calvin Phoebe & Joan Snyder Inst Chron Dis, Calgary, AB T2N 4N1, Canada; 4.Univ Duisburg Essen, Univ Hosp, Inst Expt Immunol & Imaging, D-45147 Essen, Germany; 5.Texas A&M Univ, Hlth Sci Ctr, Dept Med Physiol, Temple, TX 76504 USA; 6.Univ Calgary, Dept Microbiol & Infect Dis, Calgary, AB T2N 4N1, Canada |
推荐引用方式 GB/T 7714 | Wang, Jing,Hossain, Mokarram,Thanabalasuriar, Ajitha,et al. Visualizing the function and fate of neutrophils in sterile injury and repair[J]. SCIENCE,2017,358(6359):111-115. |
APA | Wang, Jing,Hossain, Mokarram,Thanabalasuriar, Ajitha,Gunzer, Matthias,Meininger, Cynthia,&Kubes, Paul.(2017).Visualizing the function and fate of neutrophils in sterile injury and repair.SCIENCE,358(6359),111-115. |
MLA | Wang, Jing,et al."Visualizing the function and fate of neutrophils in sterile injury and repair".SCIENCE 358.6359(2017):111-115. |
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