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DOI | 10.1126/science.aan0092 |
Spindle asymmetry drives non-Mendelian chromosome segregation | |
Akera, Takashi1; Chmatal, Lukas1; Trimm, Emily1; Yang, Karren1; Aonbangkhen, Chanat2; Chenoweth, David M.2; Janke, Carsten3,4; Schultz, Richard M.1; Lampson, Michael A.1 | |
2017-11-03 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 358期号:6363页码:668-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA; France |
英文摘要 | Genetic elements compete for transmission through meiosis, when haploid gametes are created from a diploid parent. Selfish elements can enhance their transmission through a process known as meiotic drive. In female meiosis, selfish elements drive by preferentially attaching to the egg side of the spindle. This implies some asymmetry between the two sides of the spindle, but the molecular mechanisms underlying spindle asymmetry are unknown. Here we found that CDC42 signaling from the cell cortex regulated microtubule tyrosination to induce spindle asymmetry and that non-Mendelian segregation depended on this asymmetry. Cortical CDC42 depends on polarization directed by chromosomes, which are positioned near the cortex to allow the asymmetric cell division. Thus, selfish meiotic drivers exploit the asymmetry inherent in female meiosis to bias their transmission. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000414240500042 |
WOS关键词 | MEIOTIC DRIVE ; SYMMETRY-BREAKING ; MEIOSIS ; OOCYTES ; EVOLUTION ; MESHWORK ; LIGHT |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197251 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Univ Penn, Dept Biol, Sch Arts & Sci, Philadelphia, PA 19104 USA; 2.Univ Penn, Dept Chem, Sch Arts & Sci, Philadelphia, PA 19104 USA; 3.Paris Sci & Lettres PSL Res Univ, Inst Curie, CNRS UMR3348, Ctr Univ, Batiment 110, F-91405 Orsay, France; 4.Univ Paris Saclay, Univ Paris Sud, CNRS UMR3348, Ctr Univ, Batiment 110, F-91405 Orsay, France |
推荐引用方式 GB/T 7714 | Akera, Takashi,Chmatal, Lukas,Trimm, Emily,et al. Spindle asymmetry drives non-Mendelian chromosome segregation[J]. SCIENCE,2017,358(6363):668-+. |
APA | Akera, Takashi.,Chmatal, Lukas.,Trimm, Emily.,Yang, Karren.,Aonbangkhen, Chanat.,...&Lampson, Michael A..(2017).Spindle asymmetry drives non-Mendelian chromosome segregation.SCIENCE,358(6363),668-+. |
MLA | Akera, Takashi,et al."Spindle asymmetry drives non-Mendelian chromosome segregation".SCIENCE 358.6363(2017):668-+. |
条目包含的文件 | 条目无相关文件。 |
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