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DOI | 10.1126/science.aao3265 |
SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway | |
Gu, Xin1,2,3,4,5,6; Orozco, Jose M.1,2,3,4,5,6; Saxton, Robert A.1,2,3,4,5,6; Condon, Kendall J.1,2,3,4,5,6; Liu, Grace Y.1,2,3,4,5,6; Krawczyk, Patrycja A.1,2,3,4,5,6; Scaria, Sonia M.1,2,3,4,5,6; Harper, J. Wade7; Gygi, Steven P.7; Sabatini, David M.1,2,3,4,5,6 | |
2017-11-10 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 358期号:6364页码:813-818 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | mTOR complex 1 (mTORC1) regulates cell growth and metabolism in response to multiple environmental cues. Nutrients signal via the Rag guanosine triphosphatases (GTPases) to promote the localization of mTORC1 to the lysosomal surface, its site of activation. We identified SAMTOR, a previously uncharacterized protein, which inhibits mTORC1 signaling by interacting with GATOR1, the GTPase activating protein (GAP) for RagA/B. We found that the methyl donor S-adenosylmethionine (SAM) disrupts the SAMTOR-GATOR1 complex by binding directly to SAMTOR with a dissociation constant of approximately 7 mu M. In cells, methionine starvation reduces SAM levels below this dissociation constant and promotes the association of SAMTOR with GATOR1, thereby inhibiting mTORC1 signaling in a SAMTOR-dependent fashion. Methionine-induced activation of mTORC1 requires the SAM binding capacity of SAMTOR. Thus, SAMTOR is a SAM sensor that links methionine and one-carbon metabolism to mTORC1 signaling. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000414847100050 |
WOS关键词 | LIFE-SPAN EXTENSION ; AMINO-ACID LEVELS ; RAG GTPASES ; METHIONINE RESTRICTION ; HISTONE METHYLATION ; DIETARY METHIONINE ; TUMOR-SUPPRESSOR ; METABOLISM ; UPSTREAM ; COMPLEX |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197283 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Whitehead Inst Biomed Res, 9 Cambridge Ctr, Cambridge, MA 02142 USA; 2.MIT, Dept Biol, 77 Massachusetts Ave, Cambridge, MA 02142 USA; 3.MIT, Dept Biol, Howard Hughes Med Inst, 77 Massachusetts Ave, Cambridge, MA 02139 USA; 4.MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA; 5.MIT, Dept Biol, 77 Massachusetts Ave, Cambridge, MA 02139 USA; 6.Broad Inst Harvard & MIT, Cambridge, MA 02142 USA; 7.Harvard Med Sch, Dept Cell Biol, Boston, MA 02115 USA |
推荐引用方式 GB/T 7714 | Gu, Xin,Orozco, Jose M.,Saxton, Robert A.,et al. SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway[J]. SCIENCE,2017,358(6364):813-818. |
APA | Gu, Xin.,Orozco, Jose M..,Saxton, Robert A..,Condon, Kendall J..,Liu, Grace Y..,...&Sabatini, David M..(2017).SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway.SCIENCE,358(6364),813-818. |
MLA | Gu, Xin,et al."SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway".SCIENCE 358.6364(2017):813-818. |
条目包含的文件 | 条目无相关文件。 |
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