GSTDTAP  > 地球科学
DOI10.1126/science.aao1140
The structural basis of flagellin detection by NAIP5: A strategy to limit pathogen immune evasion
Tenthorey, Jeannette L.1; Haloupek, Nicole1; Ramon Lopez-Blanco, Jose2; Grob, Patricia3; Adamson, Elise1,4; Hartenian, Ella1; Lind, Nicholas A.1; Bourgeois, Natasha M.1; Chacon, Pablo2; Nogales, Eva1,3,5; Vance, Russell E.1,3,6,7
2017-11-17
发表期刊SCIENCE
ISSN0036-8075
EISSN1095-9203
出版年2017
卷号358期号:6365页码:888-+
文章类型Article
语种英语
国家USA; Spain
英文摘要

Robust innate immune detection of rapidly evolving pathogens is critical for host defense. Nucleotide-binding domain leucine-rich repeat (NLR) proteins function as cytosolic innate immune sensors in plants and animals. However, the structural basis for ligand-induced NLR activation has so far remained unknown. NAIP5 (NLR family, apoptosis inhibitory protein 5) binds the bacterial protein flagellin and assembleswithNLRC4 to form amultiprotein complex called an inflammasome. Here we report the cryo-electron microscopy structure of the assembled similar to 1.4-megadalton flagellin-NAIP5-NLRC4 inflammasome, revealing how a ligand activates an NLR. Six distinct NAIP5 domains contact multiple conserved regions of flagellin, prying NAIP5 into an open and active conformation. We show that innate immune recognition of multiple ligand surfaces is a generalizable strategy that limits pathogen evolution and immune escape.


领域地球科学 ; 气候变化 ; 资源环境
收录类别SCI-E
WOS记录号WOS:000415293000038
WOS关键词BACTERIAL LIGANDS ; TERMINAL REGIONS ; RECOGNITION ; NLRC4 ; ACTIVATION ; RECEPTORS ; FILAMENT ; REVEALS ; PROTEIN ; SYSTEM
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
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文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/197346
专题地球科学
资源环境科学
气候变化
作者单位1.Univ Calif Berkeley, Dept Mol & Cell Biol, 229 Stanley Hall, Berkeley, CA 94720 USA;
2.CSIC, Inst Quim Fis Rocasolano, Dept Quim Fis Biol, Madrid 28006, Spain;
3.Univ Calif Berkeley, Howard Hughes Med Inst, Berkeley, CA 94720 USA;
4.Univ Maryland Baltimore Cty, Baltimore, MD 21250 USA;
5.Lawrence Berkeley Natl Lab, Mol Biophys & Integrat Bioimaging Div, Berkeley, CA 94720 USA;
6.Univ Calif Berkeley, Canc Res Lab & Immunotherapeut, Berkeley, CA 94720 USA;
7.Univ Calif Berkeley, Vaccine Res Initiat, Berkeley, CA 94720 USA
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Tenthorey, Jeannette L.,Haloupek, Nicole,Ramon Lopez-Blanco, Jose,et al. The structural basis of flagellin detection by NAIP5: A strategy to limit pathogen immune evasion[J]. SCIENCE,2017,358(6365):888-+.
APA Tenthorey, Jeannette L..,Haloupek, Nicole.,Ramon Lopez-Blanco, Jose.,Grob, Patricia.,Adamson, Elise.,...&Vance, Russell E..(2017).The structural basis of flagellin detection by NAIP5: A strategy to limit pathogen immune evasion.SCIENCE,358(6365),888-+.
MLA Tenthorey, Jeannette L.,et al."The structural basis of flagellin detection by NAIP5: A strategy to limit pathogen immune evasion".SCIENCE 358.6365(2017):888-+.
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