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DOI | 10.1126/science.aao5676 |
Vasohibins encode tubulin detyrosinating activity | |
Nieuwenhuis, Joppe1; Adamopoulos, Athanassios1; Bleijerveld, Onno B.1; Mazouzi, Abdelghani1; Stickel, Elmer1; Celie, Patrick1; Altelaar, Maarten1,2; Knipscheer, Puck3,4; Perrakis, Anastassis1; Blomen, Vincent A.1; Brummelkamp, Thijn R.1,4,5 | |
2017-12-15 | |
发表期刊 | SCIENCE
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ISSN | 0036-8075 |
EISSN | 1095-9203 |
出版年 | 2017 |
卷号 | 358期号:6369页码:1453-1456 |
文章类型 | Article |
语种 | 英语 |
国家 | Netherlands; Austria |
英文摘要 | Tubulin is subjected to a number of posttranslational modifications to generate heterogeneous microtubules. The modifications include removal and ligation of the C-terminal tyrosine of alpha-tubulin. The enzymes responsible for detyrosination, an activity first observed 40 years ago, have remained elusive. We applied a genetic screen in haploid human cells to find regulators of tubulin detyrosination. We identified SVBP, a peptide that regulates the abundance of vasohibins (VASH1 and VASH2). Vasohibins, but not SVBP alone, increased detyrosination of alpha-tubulin, and purified vasohibins removed the C-terminal tyrosine of alpha-tubulin. We found that vasohibins play a cell type-dependent role in detyrosination, although cells also contain an additional detyrosinating activity. Thus, vasohibins, hitherto studied as secreted angiogenesis regulators, constitute a long-sought missing link in the tubulin tyrosination cycle. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000417918500046 |
WOS关键词 | MICROTUBULES ; ROLES |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/197554 |
专题 | 地球科学 资源环境科学 气候变化 |
作者单位 | 1.Netherlands Canc Inst, Div Biochem, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands; 2.Univ Utrecht, Utrecht Inst Pharmaceut Sci, Biomol Mass Spectrometry & Prote, NL-3584 CH Utrecht, Netherlands; 3.Univ Med Ctr Utrecht, Hubrecht Inst KNAW, NL-3584 CT Utrecht, Netherlands; 4.CGC Nl, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands; 5.Austrian Acad Sci, CeMM Res Ctr Mol Med, A-1090 Vienna, Austria |
推荐引用方式 GB/T 7714 | Nieuwenhuis, Joppe,Adamopoulos, Athanassios,Bleijerveld, Onno B.,et al. Vasohibins encode tubulin detyrosinating activity[J]. SCIENCE,2017,358(6369):1453-1456. |
APA | Nieuwenhuis, Joppe.,Adamopoulos, Athanassios.,Bleijerveld, Onno B..,Mazouzi, Abdelghani.,Stickel, Elmer.,...&Brummelkamp, Thijn R..(2017).Vasohibins encode tubulin detyrosinating activity.SCIENCE,358(6369),1453-1456. |
MLA | Nieuwenhuis, Joppe,et al."Vasohibins encode tubulin detyrosinating activity".SCIENCE 358.6369(2017):1453-1456. |
条目包含的文件 | 条目无相关文件。 |
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